(4S,5R)-5-[4-(6-ethylcarbamoylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidine-3-carboxylicacid tert-butyl ester

Base Information

Chemical Name:(4S,5R)-5-[4-(6-ethylcarbamoylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidine-3-carboxylicacid tert-butyl ester
CAS No.:1454907-47-1
Molecular Formula:C₂₅H₃₂FN₃O₄
Molecular Weight:457.545
Hs Code.:

Synonyms:(4S,5R)-5-[4-(6-ethylcarbamoylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidine-3-carboxylicacid tert-butyl ester

Suppliers and Price of (4S,5R)-5-[4-(6-ethylcarbamoylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidine-3-carboxylicacid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S,5R)-5-[4-(6-ethylcarbamoylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidine-3-carboxylicacid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S,5R)-5-[4-(6-ethylcarbamoylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidine-3-carboxylicacid tert-butyl ester

There total 5 articles about (4S,5R)-5-[4-(6-ethylcarbamoylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidine-3-carboxylicacid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454907-46-0
5-[4-((4S,5R)-3-tert-butoxycarbonyl-4-fluoromethyl-2,2-dimethyloxazolidin-5-yl)phenyl]pyridine-2-carboxylic acid

: 75-04-7,85404-22-4
ethylamine

: 1454907-47-1
(4S,5R)-5-[4-(6-ethylcarbamoylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidine-3-carboxylicacid tert-butyl ester

Guidance literature:: With diisopropylamine; triphenylphosphine; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 14h;

Reference yield:

: 1052114-46-1
tert-butyl ((1R,2S)-3-fluoro-1-hydroxy-1-(4-iodophenyl)propan-2-yl)carbamate

: 1454907-47-1
(4S,5R)-5-[4-(6-ethylcarbamoylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidine-3-carboxylicacid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

2: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

4: potassium hydroxide; methanol / 48 h / 65 °C

5: diisopropylamine; triphenylphosphine / tetrahydrofuran; ethyl acetate / 14 h / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; caesium carbonate; toluene-4-sulfonic acid; diisopropylamine; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate;

Reference yield:

: 1454906-58-1
(4S,5R)-4-fluoromethyl-5-(4-iodophenyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 1454907-47-1
(4S,5R)-5-[4-(6-ethylcarbamoylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidine-3-carboxylicacid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

3: potassium hydroxide; methanol / 48 h / 65 °C

4: diisopropylamine; triphenylphosphine / tetrahydrofuran; ethyl acetate / 14 h / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; caesium carbonate; diisopropylamine; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; ethyl acetate;