ethyl 2-diazo-3-oxo-3-(2-oxo-3-(pent-4-en-1-yl(phenyl)amino)indolin-1-yl)propanoate

Base Information

• Chemical Name: ethyl 2-diazo-3-oxo-3-(2-oxo-3-(pent-4-en-1-yl(phenyl)amino)indolin-1-yl)propanoate
• CAS No.: 1515871-22-3
• Molecular Formula: C₂₄H₂₄N₄O₄
• Molecular Weight: 432.479
• Mol file: 1515871-22-3.mol

Synonyms:ethyl 2-diazo-3-oxo-3-(2-oxo-3-(pent-4-en-1-yl(phenyl)amino)indolin-1-yl)propanoate

Chemical Property of ethyl 2-diazo-3-oxo-3-(2-oxo-3-(pent-4-en-1-yl(phenyl)amino)indolin-1-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-diazo-3-oxo-3-(2-oxo-3-(pent-4-en-1-yl(phenyl)amino)indolin-1-yl)propanoate

There total 3 articles about ethyl 2-diazo-3-oxo-3-(2-oxo-3-(pent-4-en-1-yl(phenyl)amino)indolin-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

1-(ethyl diazomalonyl)-3-diazoindolin-2-one (1448623-19-5) + N-(pent-4-enyl)aniline (42331-17-9) → ethyl 2-diazo-3-oxo-3-(2-oxo-3-(pent-4-en-1-yl(phenyl)amino)indolin-1-yl)propanoate (1515871-22-3)

Guidance literature:

With rhodium(II) acetate dimer; In benzene; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jo4026622

Reference yield:

chlorocarbonyl-diazo-acetic acid ethyl ester (57072-87-4) → ethyl 2-diazo-3-oxo-3-(2-oxo-3-(pent-4-en-1-yl(phenyl)amino)indolin-1-yl)propanoate (1515871-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / Inert atmosphere; Cooling

1.2: 0.5 h / Inert atmosphere

2.1: rhodium(II) acetate dimer / benzene / 1 h / 20 °C / Inert atmosphere

With rhodium(II) acetate dimer; sodium hydride; In tetrahydrofuran; mineral oil; benzene;

DOI:10.1021/jo4026622

Reference yield:

3-diazo-indolin-2-one (3265-29-0) → ethyl 2-diazo-3-oxo-3-(2-oxo-3-(pent-4-en-1-yl(phenyl)amino)indolin-1-yl)propanoate (1515871-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / Inert atmosphere; Cooling

1.2: 0.5 h / Inert atmosphere

2.1: rhodium(II) acetate dimer / benzene / 1 h / 20 °C / Inert atmosphere

With rhodium(II) acetate dimer; sodium hydride; In tetrahydrofuran; mineral oil; benzene;

DOI:10.1021/jo4026622

upstream raw materials:

1-(ethyl diazomalonyl)-3-diazoindolin-2-one

N-(pent-4-enyl)aniline

3-diazo-indolin-2-one

chlorocarbonyl-diazo-acetic acid ethyl ester