2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine

Base Information

• Chemical Name: 2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine
• CAS No.: 1100749-90-3
• Molecular Formula: C₁₄H₁₂F₃N₃O₄S
• Molecular Weight: 375.328

Synonyms:2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine

Chemical Property of 2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine

Chemical Property:

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Technology Process of 2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine

There total 1 articles about 2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-6-ol (1100750-12-6) + 4-trifluoromethoxybenzyl bromide (50824-05-0) → 2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine (1100749-90-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2.66667h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.bmcl.2017.10.067

Reference yield: 75.0%

2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine (1100749-90-3) → 2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8,8-dioxide (1100749-94-7) + 2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxide + 2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxide

Guidance literature:

With disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -10 - 20 ℃; for 19h;

DOI:10.1016/j.bmcl.2017.10.067

Reference yield: 73.0%

2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine (1100749-90-3) → 2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8,8-dioxide (1100749-94-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1021/jm801087e

upstream raw materials:

2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-6-ol

4-trifluoromethoxybenzyl bromide

Downstream raw materials:

2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxide

2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8,8-dioxide

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