C₃₃H₅₂N₈O

Base Information

• Chemical Name: C₃₃H₅₂N₈O
• CAS No.: 1519003-75-8
• Molecular Formula: C₃₃H₅₂N₈O
• Molecular Weight: 576.829
• Mol file: 1519003-75-8.mol

Synonyms:C₃₃H₅₂N₈O

Chemical Property of C₃₃H₅₂N₈O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₅₂N₈O

There total 12 articles about C₃₃H₅₂N₈O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

C22H33N5*2ClH + 11-azidoundecanoic acid (118162-45-1) → C33H52N8O (1519003-75-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ml400370w

Reference yield:

8-benzyl-8-azabicyclo[3.2.1]octan-3-amine → C33H52N8O (1519003-75-8)

Guidance literature:

Multi-step reaction with 10 steps

1: tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

2: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

3: sodium carbonate / water; dichloromethane / 0 - 20 °C / Inert atmosphere

4: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere

6: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere

7: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr / Inert atmosphere

8: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 3 h / 0 - 20 °C / Inert atmosphere

9: hydrogenchloride / methanol; 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

10: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; phosphorus pentachloride; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; tert-Amyl alcohol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/ml400370w

Reference yield:

exo-(8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-carbamic acid tert-butyl ester (132259-54-2,287114-24-3) → C33H52N8O (1519003-75-8)

Guidance literature:

Multi-step reaction with 9 steps

1: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

2: sodium carbonate / water; dichloromethane / 0 - 20 °C / Inert atmosphere

3: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere

5: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere

6: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr / Inert atmosphere

7: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 3 h / 0 - 20 °C / Inert atmosphere

8: hydrogenchloride / methanol; 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

9: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; phosphorus pentachloride; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol; tert-Amyl alcohol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/ml400370w

upstream raw materials:

8-Benzyl-1αH,5αH-nortropan-3-one Oxime

exo-(8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-carbamic acid tert-butyl ester

C₂₀H₃₀N₄O

8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl-amine

Downstream raw materials:

C₅₅H₈₁N₉O₈