2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)-2-oxoacetic acid

Base Information

Chemical Name:2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)-2-oxoacetic acid
CAS No.:1370705-89-7
Molecular Formula:C₂₇H₂₇FN₄O₅
Molecular Weight:506.534
Hs Code.:

Synonyms:2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)-2-oxoacetic acid

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Chemical Property of 2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)-2-oxoacetic acid

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Technology Process of 2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)-2-oxoacetic acid

There total 9 articles about 2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)-2-oxoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: C₂HF₃O₂*3C₂₉H₃₁FN₄O₅

: 1370705-89-7
2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)-2-oxoacetic acid

Guidance literature:: C₂HF₃O₂*3C₂₉H₃₁FN₄O₅; With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With trifluoroacetic acid; In water; pH=2;
DOI:10.1016/j.ejmech.2012.01.059

Reference yield:

: 1056737-08-6
(2,4-dimethyl-6-nitro-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methanol

: 1370705-89-7
2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 48 h / Reflux

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

3.1: methanol / 5 h / 20 °C / Inert atmosphere; Molecular sieve

4.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

5.1: triethylamine / dichloromethane / 2 h / 20 °C

6.1: hydrogenchloride / ethanol / 24.5 h / 20 °C

6.2: 24 h / 20 °C

7.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

7.2: pH 2

With hydrogenchloride; sodium tetrahydroborate; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; triethylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1.1: Mitsunobu reaction / 6.1: Pinner amidine synthesis / 6.2: Pinner amidine synthesis;
DOI:10.1016/j.ejmech.2012.01.059

Reference yield:

: 1056737-23-5
4-[(6-amino-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy]benzonitrile

: 1370705-89-7
2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 5 h / 20 °C / Inert atmosphere; Molecular sieve

2.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

4.1: hydrogenchloride / ethanol / 24.5 h / 20 °C

4.2: 24 h / 20 °C

5.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

5.2: pH 2

With hydrogenchloride; sodium tetrahydroborate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; 4.1: Pinner amidine synthesis / 4.2: Pinner amidine synthesis;
DOI:10.1016/j.ejmech.2012.01.059