3-(3-nitro-4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Base Information

Chemical Name:3-(3-nitro-4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS No.:1603845-36-8
Molecular Formula:C₂₂H₂₁N₇O₃
Molecular Weight:431.454
Hs Code.:

Synonyms:3-(3-nitro-4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Chemical Property of 3-(3-nitro-4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Technology Process of 3-(3-nitro-4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

There total 6 articles about 3-(3-nitro-4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1603845-35-7
C₂₇H₂₉N₇O₅

: 1603845-36-8
3-(3-nitro-4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1016/j.bmcl.2015.04.103

Reference yield:

: 1603845-34-6
C₂₁H₂₄FN₇O₄

: 1603845-36-8
3-(3-nitro-4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate

2: trifluoroacetic acid / dichloromethane

With potassium carbonate; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 330793-48-1
4-(4-amino-3-iodopyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester

: 1603845-36-8
3-(3-nitro-4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 80 °C

2: potassium carbonate

3: trifluoroacetic acid / dichloromethane

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;