4-[2-(4-Benzyloxy-3-methoxy-phenyl)-2-hydroxy-1-hydroxymethyl-ethoxy]-3-methoxy-benzaldehyde

Base Information

• Chemical Name: 4-[2-(4-Benzyloxy-3-methoxy-phenyl)-2-hydroxy-1-hydroxymethyl-ethoxy]-3-methoxy-benzaldehyde
• CAS No.: 17614-27-6
• Molecular Formula: C₂₅H₂₆O₇
• Molecular Weight: 438.477
• Mol file: 17614-27-6.mol

Synonyms:4-[2-(4-Benzyloxy-3-methoxy-phenyl)-2-hydroxy-1-hydroxymethyl-ethoxy]-3-methoxy-benzaldehyde

Chemical Property of 4-[2-(4-Benzyloxy-3-methoxy-phenyl)-2-hydroxy-1-hydroxymethyl-ethoxy]-3-methoxy-benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2-(4-Benzyloxy-3-methoxy-phenyl)-2-hydroxy-1-hydroxymethyl-ethoxy]-3-methoxy-benzaldehyde

There total 2 articles about 4-[2-(4-Benzyloxy-3-methoxy-phenyl)-2-hydroxy-1-hydroxymethyl-ethoxy]-3-methoxy-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-Benzyloxy-3-methoxy-phenyl)-2-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2-methoxy-phenoxy]-propane-1,3-diol → 4-[2-(4-Benzyloxy-3-methoxy-phenyl)-2-hydroxy-1-hydroxymethyl-ethoxy]-3-methoxy-benzaldehyde (17614-27-6)

Guidance literature:

With oxalic acid; In tetrahydrofuran; methanol; Ambient temperature;

DOI:10.1016/0960-894X(96)00425-8

Reference yield:

3-(4-Benzyloxy-3-methoxy-phenyl)-2-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2-methoxy-phenoxy]-3-hydroxy-propionic acid methyl ester → 4-[2-(4-Benzyloxy-3-methoxy-phenyl)-2-hydroxy-1-hydroxymethyl-ethoxy]-3-methoxy-benzaldehyde (17614-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / DIBAH / tetrahydrofuran / 0 °C

2: 100 percent / aq. oxalic acid / tetrahydrofuran; methanol / Ambient temperature

With oxalic acid; diisobutylaluminium hydride; In tetrahydrofuran; methanol;

DOI:10.1016/0960-894X(96)00425-8

Reference yield:

4-[2-(4-Benzyloxy-3-methoxy-phenyl)-2-hydroxy-1-hydroxymethyl-ethoxy]-3-methoxy-benzaldehyde (17614-27-6) → 1-{4-[4-(4-Benzyloxy-3-methoxy-phenyl)-2,2-dimethyl-[1,3]dioxan-5-yloxy]-3-methoxy-phenyl}-2-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2-methoxy-phenoxy]-propane-1,3-diol

Guidance literature:

Multi-step reaction with 3 steps

1: CuSO₄ / Ambient temperature

With copper(II) sulfate;

DOI:10.1016/0960-894X(96)00425-8