3-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-2,5,10b-triaza-benzo[e]azulen-4-yl]-propionic acid tert-butyl ester

Base Information

• Chemical Name: 3-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-2,5,10b-triaza-benzo[e]azulen-4-yl]-propionic acid tert-butyl ester
• CAS No.: 308243-61-0
• Molecular Formula: C₂₅H₂₅ClFN₃O₂
• Molecular Weight: 453.944

Synonyms:3-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-2,5,10b-triaza-benzo[e]azulen-4-yl]-propionic acid tert-butyl ester

Chemical Property of 3-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-2,5,10b-triaza-benzo[e]azulen-4-yl]-propionic acid tert-butyl ester

Chemical Property:

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Technology Process of 3-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-2,5,10b-triaza-benzo[e]azulen-4-yl]-propionic acid tert-butyl ester

There total 1 articles about 3-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-2,5,10b-triaza-benzo[e]azulen-4-yl]-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + Midazolam (59467-70-8) → 3-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-2,5,10b-triaza-benzo[e]azulen-4-yl]-propionic acid tert-butyl ester (308243-61-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; at -10 ℃; for 1.16667h;

Reference yield:

3-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-2,5,10b-triaza-benzo[e]azulen-4-yl]-propionic acid tert-butyl ester (308243-61-0) → 3-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-2,5,10b-triaza-benzo[e]azulen-4-yl]-propionic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1.1: TFA

2.1: K₂CO₃ / dimethylformamide

2.2: chiral HPLC resolution

With potassium carbonate; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00513-9

Reference yield:

3-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-2,5,10b-triaza-benzo[e]azulen-4-yl]-propionic acid tert-butyl ester (308243-61-0) → 3-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-2,5,10b-triaza-benzo[e]azulen-4-yl]-propionic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1.1: TFA

2.1: K₂CO₃ / dimethylformamide

2.2: chiral HPLC resolution

With potassium carbonate; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00513-9

upstream raw materials:

tert-Butyl acrylate

Midazolam

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