2-cyano-3-(2-fluoro-4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)-phenyl)-N,N-dimethylacrylamide

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Chemical Name:2-cyano-3-(2-fluoro-4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)-phenyl)-N,N-dimethylacrylamide
CAS No.:1413913-13-9
Molecular Formula:C₂₉H₃₇FN₆O₃Si
Molecular Weight:564.735
Hs Code.:

Synonyms:2-cyano-3-(2-fluoro-4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)-phenyl)-N,N-dimethylacrylamide

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Chemical Property of 2-cyano-3-(2-fluoro-4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)-phenyl)-N,N-dimethylacrylamide

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Technology Process of 2-cyano-3-(2-fluoro-4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)-phenyl)-N,N-dimethylacrylamide

There total 8 articles about 2-cyano-3-(2-fluoro-4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)-phenyl)-N,N-dimethylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1413913-08-2
2-fluoro-4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)benzaldehyde

: 7391-40-4
N,N-dimethylcyanoacetamide

: 1413913-13-9
2-cyano-3-(2-fluoro-4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)-phenyl)-N,N-dimethylacrylamide

Guidance literature:: With piperidinyl acetate; In ethanol; water; at 20 - 80 ℃; for 4h;

Reference yield:

: 73792-08-2
methyl 4-amino-2-fluorobenzoate

: 1413913-13-9
2-cyano-3-(2-fluoro-4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)-phenyl)-N,N-dimethylacrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 0.25 h / 0 - 5 °C / Inert atmosphere

1.2: 1.17 h / 20 °C

2.1: DavePhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 0.17 h / Inert atmosphere

2.2: 2 h / 100 °C

3.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.1: piperidinyl acetate / ethanol; water / 4 h / 20 - 80 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; piperidinyl acetate; Dess-Martin periodane; DavePhos; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 875781-41-2
5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

: 1413913-13-9
2-cyano-3-(2-fluoro-4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)-phenyl)-N,N-dimethylacrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.83 h / 20 - 65 °C / Inert atmosphere

2.1: diethyl aluminiumcholoride / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere

2.2: 21.17 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.42 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: DavePhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 0.17 h / Inert atmosphere

4.2: 2 h / 100 °C

5.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

6.1: piperidinyl acetate / ethanol; water / 4 h / 20 - 80 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; piperidinyl acetate; diethyl aluminiumcholoride; potassium tert-butylate; sodium hydride; Dess-Martin periodane; DavePhos; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; paraffin oil;