IMidafenacin IMpurity (1-(3-Cyano-3,3-Diphenylpropyl)-2-Methyl-1H-IMidazoliuM Phosphate)

Base Information

• Chemical Name: IMidafenacin IMpurity (1-(3-Cyano-3,3-Diphenylpropyl)-2-Methyl-1H-IMidazoliuM Phosphate)
• CAS No.: 562091-56-9
• Molecular Formula: C₂₀H₁₉N₃*H₃O₄P
• Molecular Weight: 399.386
• Mol file: 562091-56-9.mol

Synonyms:4-(2-methyl-1-imidazolyl)-2,2-diphenylbutyronitrile phosphate

Chemical Property of IMidafenacin IMpurity (1-(3-Cyano-3,3-Diphenylpropyl)-2-Methyl-1H-IMidazoliuM Phosphate)

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of IMidafenacin IMpurity (1-(3-Cyano-3,3-Diphenylpropyl)-2-Methyl-1H-IMidazoliuM Phosphate)

There total 4 articles about IMidafenacin IMpurity (1-(3-Cyano-3,3-Diphenylpropyl)-2-Methyl-1H-IMidazoliuM Phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.5%

4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanenitrile (214777-43-2) → 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutyronitrile phosphate (562091-56-9)

Guidance literature:

With phosphoric acid; In ethanol; water; at 30 - 31 ℃; for 16.5h;

Reference yield: 68.0%

→ 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutyronitrile phosphate (562091-56-9)

Guidance literature:

In water; isopropyl alcohol; at 15 ℃; for 1h; Purification / work up;

Reference yield:

4-bromo-2,2-diphenylbutyronitrile (39186-58-8) → 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutyronitrile phosphate (562091-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 5 h / 40 °C

2: thionyl chloride; pyridine / tetrahydrofuran / 5 h / 50 °C

With pyridine; thionyl chloride; sodium hydroxide; In tetrahydrofuran; methanol; water;

upstream raw materials:

4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanenitrile

4-bromo-2,2-diphenylbutyronitrile

Downstream raw materials:

imidafenacin

Refernces

• 1、 -. "METHOD FOR PRODUCING 4-(2-METHYL-1-IMIDAZOLYL)-2,2-PHENYLBUTANE AMIDE". Paragraph 0029. . Retrieved 2016/12/22.