(S)-2-((R)-1-Carboxymethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-ylamino)-4-phenyl-butyric acid; hydrochloride

Base Information

Chemical Name:(S)-2-((R)-1-Carboxymethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-ylamino)-4-phenyl-butyric acid; hydrochloride
CAS No.:97278-66-5
Molecular Formula:C₂₁H₂₂N₂O₅*ClH
Molecular Weight:418.877
Hs Code.:

Synonyms:(S)-2-((R)-1-Carboxymethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-ylamino)-4-phenyl-butyric acid; hydrochloride

Suppliers and Price of (S)-2-((R)-1-Carboxymethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-ylamino)-4-phenyl-butyric acid; hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-((R)-1-Carboxymethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-ylamino)-4-phenyl-butyric acid; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-((R)-1-Carboxymethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-ylamino)-4-phenyl-butyric acid; hydrochloride

There total 5 articles about (S)-2-((R)-1-Carboxymethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-ylamino)-4-phenyl-butyric acid; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 97278-64-3,97278-65-4
(S)-2-((R)-1-Ethoxycarbonylmethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-ylamino)-4-phenyl-butyric acid ethyl ester

: 97278-66-5
(S)-2-((R)-1-Carboxymethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-ylamino)-4-phenyl-butyric acid; hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; for 16h; Heating;
DOI:10.1021/jm00148a023

Reference yield:

: 85115-10-2,40615-17-6
3-amino-1,2,3,4-tetrahydroquinolin-2-one

: 97278-66-5
(S)-2-((R)-1-Carboxymethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-ylamino)-4-phenyl-butyric acid; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium cyanoborohydride / methanol / 16 h / Ambient temperature

2: HCl / 16 h / Heating

3: 1.) NaH, Bu₄NBr / 1.) DMF, RT, 0.5 h, 2.) DMF, 50 deg C, 22 h

4: 58 percent / 3N aq. HCl / ethanol / 16 h / Heating

With hydrogenchloride; tetrabutylammomium bromide; sodium hydride; sodium cyanoborohydride; In methanol; ethanol;
DOI:10.1021/jm00148a023

Reference yield:

: 710-11-2
2-oxo-4-phenylbutyric acid

: 97278-66-5
(S)-2-((R)-1-Carboxymethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-ylamino)-4-phenyl-butyric acid; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium cyanoborohydride / methanol / 16 h / Ambient temperature

2: HCl / 16 h / Heating

3: 1.) NaH, Bu₄NBr / 1.) DMF, RT, 0.5 h, 2.) DMF, 50 deg C, 22 h

4: 58 percent / 3N aq. HCl / ethanol / 16 h / Heating

With hydrogenchloride; tetrabutylammomium bromide; sodium hydride; sodium cyanoborohydride; In methanol; ethanol;
DOI:10.1021/jm00148a023