Hexanedioic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester

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Chemical Name:Hexanedioic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester
CAS No.:201210-75-5
Molecular Formula:C₁₇H₁₂F₆N₂O₆
Molecular Weight:454.282
Hs Code.:

Synonyms:Hexanedioic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester

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Chemical Property of Hexanedioic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester

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Technology Process of Hexanedioic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester

There total 4 articles about Hexanedioic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 201210-73-3
Hexanedioic acid mono-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl) ester

: 201210-75-5
Hexanedioic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 2h; Ambient temperature;
DOI:10.1021/jo971076p

Reference yield:

: 40542-90-3
adipic acid monobenzyl ester

: 201210-75-5
Hexanedioic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / Cs₂CO₃ / dimethylformamide / 1.) room temperature, 30 min; 70 deg C, 15 min, 2.) room temperature, 3 h; 70 deg C, 15 min

2: 1.) SO₂Cl₂, 2.) cis-4-cyclohexene-1,2-dicarboxylic acid / 1.) CH₂Cl₂, room temperature, 1 h, 2.) 1 h

3: 63 percent / Et₃N / dimethylformamide / 16 h / Ambient temperature

4: 60 percent / 1,4-cyclohexadiene / Pd/C / acetic acid / 1 h / Ambient temperature

5: 77 percent / EDCI*HCl / dimethylformamide / 2 h / Ambient temperature

With sulfuryl dichloride; cyclohexa-1,4-diene; cis-1,2,3,6-tetrahydrophthalic acid; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo971076p

Reference yield:

: 201210-69-7
Hexanedioic acid benzyl ester phenylsulfanylmethyl ester

: 201210-75-5
Hexanedioic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) SO₂Cl₂, 2.) cis-4-cyclohexene-1,2-dicarboxylic acid / 1.) CH₂Cl₂, room temperature, 1 h, 2.) 1 h

2: 63 percent / Et₃N / dimethylformamide / 16 h / Ambient temperature

3: 60 percent / 1,4-cyclohexadiene / Pd/C / acetic acid / 1 h / Ambient temperature

4: 77 percent / EDCI*HCl / dimethylformamide / 2 h / Ambient temperature

With sulfuryl dichloride; cyclohexa-1,4-diene; cis-1,2,3,6-tetrahydrophthalic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo971076p