(2S,12S)-2,6-cyclo-12,16-cyclo-19-(benzyloxycarbonylamino)-6,10,16-triaza-11-oxoheptadecanoic acid methyl ester

Base Information

Chemical Name:(2S,12S)-2,6-cyclo-12,16-cyclo-19-(benzyloxycarbonylamino)-6,10,16-triaza-11-oxoheptadecanoic acid methyl ester
CAS No.:295343-31-6
Molecular Formula:C₂₅H₃₈N₄O₅
Molecular Weight:474.601
Hs Code.:

Synonyms:(2S,12S)-2,6-cyclo-12,16-cyclo-19-(benzyloxycarbonylamino)-6,10,16-triaza-11-oxoheptadecanoic acid methyl ester

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Chemical Property of (2S,12S)-2,6-cyclo-12,16-cyclo-19-(benzyloxycarbonylamino)-6,10,16-triaza-11-oxoheptadecanoic acid methyl ester

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Technology Process of (2S,12S)-2,6-cyclo-12,16-cyclo-19-(benzyloxycarbonylamino)-6,10,16-triaza-11-oxoheptadecanoic acid methyl ester

There total 6 articles about (2S,12S)-2,6-cyclo-12,16-cyclo-19-(benzyloxycarbonylamino)-6,10,16-triaza-11-oxoheptadecanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 295343-27-0
(2S)-N-(N'-(benzyloxycarbonyl)-3'-aminopropyl)-proline

: (S)-1-(3-Amino-propyl)-pyrrolidine-2-carboxylic acid methyl ester; hydrochloride

: 295343-31-6
(2S,12S)-2,6-cyclo-12,16-cyclo-19-(benzyloxycarbonylamino)-6,10,16-triaza-11-oxoheptadecanoic acid methyl ester

Guidance literature:: With triethylamine; isobutyl chloroformate; In dichloromethane; at -20 - 20 ℃;
DOI:10.1016/S0040-4039(00)00901-1

Reference yield:

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 295343-31-6
(2S,12S)-2,6-cyclo-12,16-cyclo-19-(benzyloxycarbonylamino)-6,10,16-triaza-11-oxoheptadecanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / Et₃N / acetonitrile / 20 - 50 °C

2: H₂O / Heating

3: CH₂Cl₂ / 0 - 20 °C

With water; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/S0957-4166(01)00012-X

Reference yield:

: 295343-25-8
(2S)-N-(N'-(benzyloxycarbonyl)-3'-aminopropyl)-proline methyl ester

: 295343-31-6
(2S,12S)-2,6-cyclo-12,16-cyclo-19-(benzyloxycarbonylamino)-6,10,16-triaza-11-oxoheptadecanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂O / Heating

2: CH₂Cl₂ / 0 - 20 °C

With water; In dichloromethane;
DOI:10.1016/S0957-4166(01)00012-X