(-)-(1R,2S)-2-phenylcyclohexyl 5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxylate

Base Information

Chemical Name:(-)-(1R,2S)-2-phenylcyclohexyl 5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxylate
CAS No.:888034-71-7
Molecular Formula:C₂₆H₂₉NO₃
Molecular Weight:403.521
Hs Code.:

Synonyms:(-)-(1R,2S)-2-phenylcyclohexyl 5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxylate

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Chemical Property of (-)-(1R,2S)-2-phenylcyclohexyl 5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxylate

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Technology Process of (-)-(1R,2S)-2-phenylcyclohexyl 5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxylate

There total 2 articles about (-)-(1R,2S)-2-phenylcyclohexyl 5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 888034-61-5
5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxylic acid

: 98919-68-7
(1R,2S)-trans-2-phenylcyclohexanol

: 888034-71-7
(-)-(1R,2S)-2-phenylcyclohexyl 5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In diethyl ether; at 18 ℃; for 48h;
DOI:10.1021/jo0602569

Reference yield:

: 2904-57-6
mesitylenecarbonitrile oxide

: 888034-71-7
(-)-(1R,2S)-2-phenylcyclohexyl 5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / tetrahydrofuran / 48 h / Heating

2: 87 percent / DMAP; DCC / diethyl ether / 48 h / 18 °C

With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo0602569

Reference yield:

: 888034-71-7
(-)-(1R,2S)-2-phenylcyclohexyl 5-methyl-3-(2,4,6-trimethylphenyl)isoxazole-4-carboxylate

: (S)-2-Phenyl-propionic acid 5-methyl-3-(2,4,6-trimethyl-phenyl)-4,5-dihydro-isoxazol-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium borohydride

2: DCC; DMAP

With dmap; sodium tetrahydroborate; dicyclohexyl-carbodiimide;
DOI:10.1021/jo0602569