2-(3-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylsulfanyl]-ethoxy}-propoxy)-6-{3-[2-((S)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-propoxy}-benzoic acid

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Chemical Name:2-(3-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylsulfanyl]-ethoxy}-propoxy)-6-{3-[2-((S)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-propoxy}-benzoic acid
CAS No.:130157-38-9
Molecular Formula:C₃₈H₅₃N₃O₁₃S₂
Molecular Weight:823.983
Hs Code.:

2-(3-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylsulfanyl]-ethoxy}-propoxy)-6-{3-[2-((S)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-propoxy}-benzoic acid

Synonyms:2-(3-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylsulfanyl]-ethoxy}-propoxy)-6-{3-[2-((S)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-propoxy}-benzoic acid

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Chemical Property of 2-(3-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylsulfanyl]-ethoxy}-propoxy)-6-{3-[2-((S)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-propoxy}-benzoic acid

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Technology Process of 2-(3-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylsulfanyl]-ethoxy}-propoxy)-6-{3-[2-((S)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-propoxy}-benzoic acid

There total 14 articles about 2-(3-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylsulfanyl]-ethoxy}-propoxy)-6-{3-[2-((S)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-propoxy}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 15761-38-3
L-N-Boc-Ala

: 130157-35-6
2-(3-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylsulfanyl]-ethoxy}-propoxy)-6-[3-(2-mercapto-ethoxy)-propoxy]-benzoic acid

: 130157-38-9
2-(3-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylsulfanyl]-ethoxy}-propoxy)-6-{3-[2-((R)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-propoxy}-benzoic acid

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 2h;
DOI:10.1016/S0040-4020(01)87908-4

Reference yield: 85.0%

: 15761-38-3
L-N-Boc-Ala

: 130157-35-6
2-(3-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylsulfanyl]-ethoxy}-propoxy)-6-[3-(2-mercapto-ethoxy)-propoxy]-benzoic acid

: 130157-38-9
2-(3-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylsulfanyl]-ethoxy}-propoxy)-6-{3-[2-((S)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-propoxy}-benzoic acid

Guidance literature:: With diphenyl-phosphinic acid; In N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(90)80187-Q

Reference yield:

: 131326-24-4
3-[2-(benzyloxy)ethoxy]-1-propanol

: 130157-38-9
2-(3-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionylsulfanyl]-ethoxy}-propoxy)-6-{3-[2-((R)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-propoxy}-benzoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 85 percent / pyridine / 4-dimethylaminopyridine (DMAP) / 3 h / 0 °C

2: 1. Cs₂CO₃ / 1. DMF, 30min; 2. DMF, 10h, r.t.

3: 99 percent / H₂ / 10percent Pd-C / methanol / 1 h

4: 84 percent / diethyl azodicarboxylate (DEAD), PPh₃ / tetrahydrofuran / a.) 1h, 0 deg C, b.) 2h, r.t.

5: 85 percent / MeONa / methanol / 0.08 h / Ambient temperature

6: 50 percent / DCC, 4-pyrrolidinopyridine (4-PP) / CH₂Cl₂ / 4 h / Ambient temperature

7: 92 percent / diphenylphosphorylazide (DPPA), triethylamine / dimethylformamide / 2 h / 0 °C

8: trifluoroacetic acid (TFA) / CH₂Cl₂ / 1 h / 0 °C

9: triethylamine / benzene / 25 °C

10: 85 percent / diphenylphosphoryl azide (DPPA), triethylamine / dimethylformamide / 2 h / 0 °C

With pyridine; diphenylphosphoranyl azide; hydrogen; sodium methylate; caesium carbonate; 4-pyrrolidin-1-ylpyridine; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; dmap; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)87908-4