6-Chloro-2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-1H-indole-5-carboxamidine

Base Information

Chemical Name:6-Chloro-2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-1H-indole-5-carboxamidine
CAS No.:277313-31-2
Molecular Formula:C₂₅H₂₄ClN₃O₃
Molecular Weight:449.937
Hs Code.:

Synonyms:6-Chloro-2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-1H-indole-5-carboxamidine

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Chemical Property of 6-Chloro-2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-1H-indole-5-carboxamidine

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Technology Process of 6-Chloro-2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-1H-indole-5-carboxamidine

There total 7 articles about 6-Chloro-2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-1H-indole-5-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: C₂₇H₂₆ClN₃O₅

: 277313-31-2
6-Chloro-2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-1H-indole-5-carboxamidine

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In acetic acid; for 6h; under 760.051 Torr;

Reference yield:

: 20925-27-3
4-amino-2-chlorobenzonitrile

: 277313-31-2
6-Chloro-2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-1H-indole-5-carboxamidine

Guidance literature:: Multi-step reaction with 7 steps

1: 48 percent / NIS; AcOH

2: 47 percent / DIEA; DMAP / CH₂Cl₂ / 0 °C

3: Et₃N; Pd(PPh₃)2Cl₂; CuI / dimethylformamide

4: 1 N aq. NaOH / dioxane; methanol / 3 h

5: 50percent aq. H₂NOH / ethanol / 4 h / Heating

6: AcOH / 1 h

7: Zn; AcOH / 4 h

With dmap; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; N-iodo-succinimide; copper(l) iodide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010244+

Reference yield:

: 380241-58-7
4-amino-2-chloro-5-iodobenzonitrile

: 277313-31-2
6-Chloro-2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-1H-indole-5-carboxamidine

Guidance literature:: Multi-step reaction with 6 steps

1: 47 percent / DIEA; DMAP / CH₂Cl₂ / 0 °C

2: Et₃N; Pd(PPh₃)2Cl₂; CuI / dimethylformamide

3: 1 N aq. NaOH / dioxane; methanol / 3 h

4: 50percent aq. H₂NOH / ethanol / 4 h / Heating

5: AcOH / 1 h

6: Zn; AcOH / 4 h

With dmap; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper(l) iodide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010244+