2,5-bis(4-acetoxy-3,5-dibromobenzoyl)-3,4-bis(4-acetoxy-3,5-dibromophenyl)-1-[2-(4-acetoxyphenyl)ethyl]-1H-pyrrole

Base Information

Chemical Name:2,5-bis(4-acetoxy-3,5-dibromobenzoyl)-3,4-bis(4-acetoxy-3,5-dibromophenyl)-1-[2-(4-acetoxyphenyl)ethyl]-1H-pyrrole
CAS No.:470448-72-7
Molecular Formula:C₄₈H₃₁Br₈NO₁₂
Molecular Weight:1453.01
Hs Code.:

Synonyms:2,5-bis(4-acetoxy-3,5-dibromobenzoyl)-3,4-bis(4-acetoxy-3,5-dibromophenyl)-1-[2-(4-acetoxyphenyl)ethyl]-1H-pyrrole

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Chemical Property of 2,5-bis(4-acetoxy-3,5-dibromobenzoyl)-3,4-bis(4-acetoxy-3,5-dibromophenyl)-1-[2-(4-acetoxyphenyl)ethyl]-1H-pyrrole

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Technology Process of 2,5-bis(4-acetoxy-3,5-dibromobenzoyl)-3,4-bis(4-acetoxy-3,5-dibromophenyl)-1-[2-(4-acetoxyphenyl)ethyl]-1H-pyrrole

There total 6 articles about 2,5-bis(4-acetoxy-3,5-dibromobenzoyl)-3,4-bis(4-acetoxy-3,5-dibromophenyl)-1-[2-(4-acetoxyphenyl)ethyl]-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 60037-43-6
2-(4-acetoxyphenyl)ethanol

: 470448-71-6
2,5-bis(4-acetoxy-3,5-dibromobenzoyl)-3,4-bis(4-acetoxy-3,5-dibromophenyl)-1H-pyrrole

: 470448-72-7
2,5-bis(4-acetoxy-3,5-dibromobenzoyl)-3,4-bis(4-acetoxy-3,5-dibromophenyl)-1-[2-(4-acetoxyphenyl)ethyl]-1H-pyrrole

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/ol026555b

Reference yield:

: 2234-38-0
3,4-bis(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid

: 470448-72-7
2,5-bis(4-acetoxy-3,5-dibromobenzoyl)-3,4-bis(4-acetoxy-3,5-dibromophenyl)-1-[2-(4-acetoxyphenyl)ethyl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl chloride / DMF / CH₂Cl₂ / 2 h / 20 °C

2: 266 mg / AlCl₃ / CH₂Cl₂ / 12 h / 20 °C

3: AlI₃; n-Bu₄NI / benzene / 12 h / Heating

4: 83 percent / bromine; acetic acid / 48 h / 20 °C

5: 99 percent / Et₃N / CH₂Cl₂ / 20 °C

6: 64 percent / PPh₃; DEAD / tetrahydrofuran / 2 h / Heating

With aluminium(III) iodide; aluminium trichloride; oxalyl dichloride; bromine; tetra-(n-butyl)ammonium iodide; acetic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; benzene; 2: Friedel-Crafts reaction / 6: Mitsunobu coupling reaction;
DOI:10.1021/ol026555b

Reference yield:

: 272118-06-6
polycitone B

: 470448-72-7
2,5-bis(4-acetoxy-3,5-dibromobenzoyl)-3,4-bis(4-acetoxy-3,5-dibromophenyl)-1-[2-(4-acetoxyphenyl)ethyl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / Et₃N / CH₂Cl₂ / 20 °C

2: 64 percent / PPh₃; DEAD / tetrahydrofuran / 2 h / Heating

With triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 2: Mitsunobu coupling reaction;
DOI:10.1021/ol026555b