Trimethyl-((3R,5S)-2-methyl-5-trityloxymethyl-tetrahydro-furan-3-yloxy)-silane

Base Information

Chemical Name:Trimethyl-((3R,5S)-2-methyl-5-trityloxymethyl-tetrahydro-furan-3-yloxy)-silane
CAS No.:313646-62-7
Molecular Formula:C₂₈H₃₄O₃Si
Molecular Weight:446.662
Hs Code.:

Synonyms:Trimethyl-((3R,5S)-2-methyl-5-trityloxymethyl-tetrahydro-furan-3-yloxy)-silane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Trimethyl-((3R,5S)-2-methyl-5-trityloxymethyl-tetrahydro-furan-3-yloxy)-silane

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Technology Process of Trimethyl-((3R,5S)-2-methyl-5-trityloxymethyl-tetrahydro-furan-3-yloxy)-silane

There total 5 articles about Trimethyl-((3R,5S)-2-methyl-5-trityloxymethyl-tetrahydro-furan-3-yloxy)-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Trimethyl-((3R,5S)-2-methylene-5-trityloxymethyl-tetrahydro-furan-3-yloxy)-silane

: (2R,3R,5S)-2-Methyl-5-trityloxymethyl-tetrahydro-furan-3-ol

: 313646-47-8
(2S,3R,5S)-2-Methyl-5-trityloxymethyl-tetrahydro-furan-3-ol

: 313646-62-7
Trimethyl-((3R,5S)-2-methyl-5-trityloxymethyl-tetrahydro-furan-3-yloxy)-silane

Guidance literature:: With hydrogen; nickel; In tetrahydrofuran; under 1500.12 Torr;
DOI:10.1016/S0040-4039(00)01435-0

Reference yield:

: 78508-96-0
(5S)-5-(hydroxymethyl)-5H-furan-2-one

: 313646-62-7
Trimethyl-((3R,5S)-2-methyl-5-trityloxymethyl-tetrahydro-furan-3-yloxy)-silane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 83 percent / pyridine / 16 h / 70 °C

2.1: 96 percent / H₂ / Pd on CaCO₃ / tetrahydrofuran / 1500.12 Torr

3.1: LiHMDS / -78 °C

3.2: MoOPH / 0.5 h / -25 °C

4.1: 86 percent / pyridine / 0 - 20 °C

5.1: tetrahydrofuran; toluene; pyridine / -40 °C

6.1: H₂ / Raney Ni / tetrahydrofuran / 1500.12 Torr

With pyridine; hydrogen; lithium hexamethyldisilazane; Lindlar's catalyst; nickel; In tetrahydrofuran; pyridine; toluene; 1.1: tritylation / 2.1: Catalytic hydrogenation / 3.1: deprotonation / 3.2: Oxidation / 4.1: Etherification / 5.1: methylenation / 6.1: Catalytic hydrogenation;
DOI:10.1016/S0040-4039(00)01435-0

Reference yield:

: 313646-40-1
(3R,5S)-3-Hydroxy-5-trityloxymethyl-dihydro-furan-2-one

: 313646-62-7
Trimethyl-((3R,5S)-2-methyl-5-trityloxymethyl-tetrahydro-furan-3-yloxy)-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / pyridine / 0 - 20 °C

2: tetrahydrofuran; toluene; pyridine / -40 °C

3: H₂ / Raney Ni / tetrahydrofuran / 1500.12 Torr

With pyridine; hydrogen; nickel; In tetrahydrofuran; pyridine; toluene; 1: Etherification / 2: methylenation / 3: Catalytic hydrogenation;
DOI:10.1016/S0040-4039(00)01435-0