2-{4-chloro-3-[(2,6-dimethyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

Base Information

Chemical Name:2-{4-chloro-3-[(2,6-dimethyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid
CAS No.:848846-61-7
Molecular Formula:C₂₉H₃₁ClN₂O₅
Molecular Weight:523.029
Hs Code.:

Synonyms:2-{4-chloro-3-[(2,6-dimethyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

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Chemical Property of 2-{4-chloro-3-[(2,6-dimethyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

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Technology Process of 2-{4-chloro-3-[(2,6-dimethyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

There total 11 articles about 2-{4-chloro-3-[(2,6-dimethyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₃ClN₂O₅

: 848846-61-7
2-{4-chloro-3-[(2,6-dimethyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

Guidance literature:: C₃₀H₃₃ClN₂O₅; With sodium hydroxide; In 1,4-dioxane; methanol; water; at 20 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; water;
DOI:10.1016/j.bmc.2011.08.065

Reference yield:

: 1351163-90-0
methyl 2,6-dimethyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoate

: 848846-61-7
2-{4-chloro-3-[(2,6-dimethyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / 1,4-dioxane; 2-ethoxy-ethanol; water / 120 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / 1 h / 40 °C

3: pyridine / dichloromethane / 20 °C

4: sodium hydroxide / 1,4-dioxane; methanol; water / 2 h / 20 °C

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In 1,4-dioxane; methanol; 2-ethoxy-ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2011.08.065

Reference yield:

: 1116624-25-9
2,6-dimethyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoic acid

: 848846-61-7
2-{4-chloro-3-[(2,6-dimethyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / 1 h / 40 °C

2: pyridine / dichloromethane / 20 °C

3: sodium hydroxide / 1,4-dioxane; methanol; water / 2 h / 20 °C

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2011.08.065