1-((4-chlorophenyl)ethynyl)-2-ethynylbenzene

Base Information

Chemical Name:1-((4-chlorophenyl)ethynyl)-2-ethynylbenzene
CAS No.:1415461-96-9
Molecular Formula:C₁₆H₉Cl
Molecular Weight:236.7
Hs Code.:

Synonyms:1-((4-chlorophenyl)ethynyl)-2-ethynylbenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-((4-chlorophenyl)ethynyl)-2-ethynylbenzene

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Technology Process of 1-((4-chlorophenyl)ethynyl)-2-ethynylbenzene

There total 7 articles about 1-((4-chlorophenyl)ethynyl)-2-ethynylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1415461-89-0
C₁₉H₁₇ClSi

: 1415461-96-9
1-((4-chlorophenyl)ethynyl)-2-ethynylbenzene

Guidance literature:: With potassium carbonate; In tetrahydrofuran; methanol; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/acs.orglett.9b01590

Reference yield: 87.0%

: 766-50-7
(2-iodophenyl)-acetylene

: [2-(4-chlorophenyl)ethynyl]diphenylphosphine oxide

: 1415461-96-9
1-((4-chlorophenyl)ethynyl)-2-ethynylbenzene

Guidance literature:: [2-(4-chlorophenyl)ethynyl]diphenylphosphine oxide; With potassium tert-butylate; tributyltin methoxide; In tetrahydrofuran; for 4.5h; Inert atmosphere; Reflux;

(2-iodophenyl)-acetylene; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.3184/174751918X15258743466204

Reference yield:

: 873-73-4
4-n-chlorophenylacetylene

: 1415461-96-9
1-((4-chlorophenyl)ethynyl)-2-ethynylbenzene

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 8 h / Inert atmosphere

2: copper(l) iodide; triethylamine; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine / toluene / 8 h / Inert atmosphere

3: potassium carbonate / methanol; tetrahydrofuran / 8 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; toluene; 1: |Sonogashira Cross-Coupling / 2: |Sonogashira Cross-Coupling;
DOI:10.1021/ol302922t