N-[(S)-1-((R)-Benzenesulfinylmethyl)-2-methyl-propyl]-phthalamic acid methyl ester

Base Information

Chemical Name:N-[(S)-1-((R)-Benzenesulfinylmethyl)-2-methyl-propyl]-phthalamic acid methyl ester
CAS No.:209788-08-9
Molecular Formula:C₂₀H₂₃NO₄S
Molecular Weight:373.473
Hs Code.:

Synonyms:N-[(S)-1-((R)-Benzenesulfinylmethyl)-2-methyl-propyl]-phthalamic acid methyl ester

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Chemical Property of N-[(S)-1-((R)-Benzenesulfinylmethyl)-2-methyl-propyl]-phthalamic acid methyl ester

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Technology Process of N-[(S)-1-((R)-Benzenesulfinylmethyl)-2-methyl-propyl]-phthalamic acid methyl ester

There total 5 articles about N-[(S)-1-((R)-Benzenesulfinylmethyl)-2-methyl-propyl]-phthalamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 4397-55-1
phthalic monoacid monomethyl ester chloride

: 209788-03-4
(S)-1-((R)-Benzenesulfinylmethyl)-2-methyl-propylamine

: 209788-08-9
N-[(S)-1-((R)-Benzenesulfinylmethyl)-2-methyl-propyl]-phthalamic acid methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1016/S0040-4020(98)00317-2

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 209788-08-9
N-[(S)-1-((R)-Benzenesulfinylmethyl)-2-methyl-propyl]-phthalamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / acetonitrile / 3 h / 20 °C

2: 70 percent / tributylphosphine / tetrahydrofuran / 72 h / 76 °C

3: sodium hypochlorite; potassium bromide; NaHCO₃ / 2,2,6,6-tetramethylpiperidine-1-oxyl / CH₂Cl₂; H₂O / 0 °C

4: 98 percent / CF₃COOH / CH₂Cl₂ / 0.75 h / 20 °C

5: 73 percent / Et₃N / tetrahydrofuran / 1 h / 0 °C

With sodium hypochlorite; tributylphosphine; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; In tetrahydrofuran; dichloromethane; water; acetonitrile; 1: Acylation / 2: Condensation / 3: Oxidation / 4: acidolysis / 5: Acylation;
DOI:10.1016/S0040-4020(98)00317-2

Reference yield:

: 79069-14-0
(S)-2-<(tert-butoxycarbonyl)amino>-3-methylbutan-1-ol

: 209788-08-9
N-[(S)-1-((R)-Benzenesulfinylmethyl)-2-methyl-propyl]-phthalamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / tributylphosphine / tetrahydrofuran / 72 h / 76 °C

2: sodium hypochlorite; potassium bromide; NaHCO₃ / 2,2,6,6-tetramethylpiperidine-1-oxyl / CH₂Cl₂; H₂O / 0 °C

3: 98 percent / CF₃COOH / CH₂Cl₂ / 0.75 h / 20 °C

4: 73 percent / Et₃N / tetrahydrofuran / 1 h / 0 °C

With sodium hypochlorite; tributylphosphine; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; In tetrahydrofuran; dichloromethane; water; 1: Condensation / 2: Oxidation / 3: acidolysis / 4: Acylation;
DOI:10.1016/S0040-4020(98)00317-2