6-chloro-3-hydroxy-7-methoxy-3-(2-hydroxy-5-methyl-3-t-butylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinoline

Base Information

Chemical Name:6-chloro-3-hydroxy-7-methoxy-3-(2-hydroxy-5-methyl-3-t-butylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinoline
CAS No.:102249-26-3
Molecular Formula:C₂₁H₂₂ClNO₅
Molecular Weight:403.862
Hs Code.:

Synonyms:6-chloro-3-hydroxy-7-methoxy-3-(2-hydroxy-5-methyl-3-t-butylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinoline

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Chemical Property of 6-chloro-3-hydroxy-7-methoxy-3-(2-hydroxy-5-methyl-3-t-butylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinoline

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Technology Process of 6-chloro-3-hydroxy-7-methoxy-3-(2-hydroxy-5-methyl-3-t-butylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinoline

There total 4 articles about 6-chloro-3-hydroxy-7-methoxy-3-(2-hydroxy-5-methyl-3-t-butylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 2409-55-4
2-tert-Butyl-4-methylphenol

: 102249-24-1
6-chloro-3,3-(dimorpholin-4-yl)-7-methoxy-2,4-dioxo-1,2,3,4-tetrahydroquinoline

: 102249-26-3
6-chloro-3-hydroxy-7-methoxy-3-(2-hydroxy-5-methyl-3-t-butylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinoline

Guidance literature:: With sulfuric acid; In water; acetic acid; for 2h; Ambient temperature;
DOI:10.1002/jhet.5570220431

Reference yield:

: 27037-34-9
4-hydroxy-7-methoxy-2-oxo-1,2-dihydroquinoline

: 102249-26-3
6-chloro-3-hydroxy-7-methoxy-3-(2-hydroxy-5-methyl-3-t-butylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / sulfuryl chloride / dioxane

2: 86 percent

3: 83 percent / conc. H₂SO₄ / acetic acid; H₂O / 2 h / Ambient temperature

With sulfuryl dichloride; sulfuric acid; In 1,4-dioxane; water; acetic acid;
DOI:10.1002/jhet.5570220431

Reference yield:

: 536-90-3,918666-97-4
m-Anisidine

: 102249-26-3
6-chloro-3-hydroxy-7-methoxy-3-(2-hydroxy-5-methyl-3-t-butylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / POCl₃ / 95 °C

2: 45 percent / sulfuryl chloride / dioxane

3: 86 percent

4: 83 percent / conc. H₂SO₄ / acetic acid; H₂O / 2 h / Ambient temperature

With sulfuryl dichloride; sulfuric acid; trichlorophosphate; In 1,4-dioxane; water; acetic acid;
DOI:10.1002/jhet.5570220431