(2R,4S,5S,6R,7R,8S)-7-(3,4-dimethoxybenzyloxy)-2,4,6,8-tetramethyl-9-decene-1,5-diol

Base Information

Chemical Name:(2R,4S,5S,6R,7R,8S)-7-(3,4-dimethoxybenzyloxy)-2,4,6,8-tetramethyl-9-decene-1,5-diol
CAS No.:102852-00-6
Molecular Formula:C₂₃H₃₈O₅
Molecular Weight:394.552
Hs Code.:

Synonyms:(2R,4S,5S,6R,7R,8S)-7-(3,4-dimethoxybenzyloxy)-2,4,6,8-tetramethyl-9-decene-1,5-diol

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Chemical Property of (2R,4S,5S,6R,7R,8S)-7-(3,4-dimethoxybenzyloxy)-2,4,6,8-tetramethyl-9-decene-1,5-diol

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Technology Process of (2R,4S,5S,6R,7R,8S)-7-(3,4-dimethoxybenzyloxy)-2,4,6,8-tetramethyl-9-decene-1,5-diol

There total 5 articles about (2R,4S,5S,6R,7R,8S)-7-(3,4-dimethoxybenzyloxy)-2,4,6,8-tetramethyl-9-decene-1,5-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 113956-91-5
(2S,3R,5S,6S)-6-[(1S,2R,3S)-2-(3,4-Dimethoxy-benzyloxy)-1,3-dimethyl-pent-4-enyl]-3,5-dimethyl-tetrahydro-pyran-2-ol

: 102852-00-6
(2R,4S,5S,6R,7R,8S)-7-(3,4-dimethoxybenzyloxy)-2,4,6,8-tetramethyl-9-decene-1,5-diol

Guidance literature:: With calcium borohydride; In ethanol; for 3h; Ambient temperature;
DOI:10.1248/cpb.35.2228

Reference yield:

: 90093-98-4
(2S,3R,5S,6S)-2-isopropyloxy-3,5-dimethyl-6-<1(S)-methyl-2-hydroxyethyl>tetrahydropyran

: 102852-00-6
(2R,4S,5S,6R,7R,8S)-7-(3,4-dimethoxybenzyloxy)-2,4,6,8-tetramethyl-9-decene-1,5-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Me₂SO, (COCl)2, Et₃N / CH₂Cl₂

2: 94 percent / BF₃-Et₂O / CH₂Cl₂ / -90 °C

3: 95 percent / KCH₂S(O)Me / Ambient temperature

4: 1.) 1 N HCl; 2.) Ca(BH₄)2 / 1.) THF, 50 deg C, 12 h; 2.) EtOH, rt, 3 h

With hydrogenchloride; calcium borohydride; oxalyl dichloride; boron trifluoride diethyl etherate; potassium dimsylate; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1021/ja00275a063

Reference yield:

: 102851-95-6
(R)-2-((2S,3S,5R,6S)-6-Isopropoxy-3,5-dimethyl-tetrahydro-pyran-2-yl)-propionaldehyde

: 102852-00-6
(2R,4S,5S,6R,7R,8S)-7-(3,4-dimethoxybenzyloxy)-2,4,6,8-tetramethyl-9-decene-1,5-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / BF₃-Et₂O / CH₂Cl₂ / -90 °C

2: 95 percent / KCH₂S(O)Me / Ambient temperature

3: 1.) 1 N HCl; 2.) Ca(BH₄)2 / 1.) THF, 50 deg C, 12 h; 2.) EtOH, rt, 3 h

With hydrogenchloride; calcium borohydride; boron trifluoride diethyl etherate; potassium dimsylate; In dichloromethane;
DOI:10.1021/ja00275a063