C₁₆H₁₉O₄P

Base Information

• Chemical Name: C₁₆H₁₉O₄P
• CAS No.: 1233656-18-2
• Molecular Formula: C₁₆H₁₉O₄P
• Molecular Weight: 306.298
• Mol file: 1233656-18-2.mol

Synonyms:C₁₆H₁₉O₄P

Chemical Property of C₁₆H₁₉O₄P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₉O₄P

There total 2 articles about C₁₆H₁₉O₄P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C9H12ClO3P (1233656-16-0) + benzyl alcohol (100-51-6,185532-71-2) → C16H19O4P (1233656-18-2)

Guidance literature:

With NMI; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.5b01456

Reference yield:

5-norbornene-2,3-dimethanol (699-95-6,941567-70-0,448922-61-0) → C16H19O4P (1233656-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate; triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2: NMI / dichloromethane / 20 °C / Inert atmosphere

With dmap; triethylamine; trichlorophosphate; In dichloromethane;

DOI:10.1021/acs.joc.5b01456

Reference yield:

C16H19O4P (1233656-18-2) + benzylamine (100-46-9) → tribenzylamine (620-40-6) + dibenzylamine (103-49-1)

Guidance literature:

C₁₆H₁₉O₄P; With Grubbs catalyst first generation; In dichloromethane; at 50 ℃; Inert atmosphere;

benzylamine; With tetra-(n-butyl)ammonium iodide; potassium carbonate; In chloroform; at 80 ℃; Inert atmosphere;

DOI:10.1021/ol1006604

upstream raw materials:

C₉H₁₂ClO₃P

benzyl alcohol

5-norbornene-2,3-dimethanol

Downstream raw materials:

N-benzylpyrrolidine

N-Benzylpiperidine

4-benzyl-morpholine

4-benzyl-thiomorpholine

Refernces

• 1、 Long, Toby R.,Maity, Pradip K.,Samarakoon, Thiwanka B.,Hanson, Paul R.. "ROMP-derived oligomeric phosphates for application in facile benzylation". supporting information; experimental part. p. 2904 - 2907. Retrieved 2010/09/30.