(E)-methyl 3-((5-(4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate

Base Information

Chemical Name:(E)-methyl 3-((5-(4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate
CAS No.:1350561-53-3
Molecular Formula:C₂₂H₃₁N₃O₂S
Molecular Weight:401.573
Hs Code.:

Synonyms:(E)-methyl 3-((5-(4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate

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Chemical Property of (E)-methyl 3-((5-(4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate

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Technology Process of (E)-methyl 3-((5-(4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate

There total 4 articles about (E)-methyl 3-((5-(4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 772-38-3
4-tert-Butylphenylacetylene

: 1350561-36-2
(E)-methyl 3-((5-azido-3-methylpent-2-en-1-yl)thio)propanoate

: 1350561-53-3
(E)-methyl 3-((5-(4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃;
DOI:10.1021/ml200106d

Reference yield:

: C₆H₁₀ClI

: 1350561-53-3
(E)-methyl 3-((5-(4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16.25 h / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 20 h / 80 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ml200106d

Reference yield:

: 1350561-33-9
(E)-5-iodo-3-methylpent-2-en-1-ol

: 1350561-53-3
(E)-methyl 3-((5-(4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-chloro-succinimide; dimethylsulfide / dichloromethane / -40 - 0 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 16.25 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 20 h / 80 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

With N-chloro-succinimide; sodium azide; copper(ll) sulfate pentahydrate; dimethylsulfide; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ml200106d