Technology Process of 2,4-dimethyl-6-phenylbenzimidazole
There total 4 articles about 2,4-dimethyl-6-phenylbenzimidazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Trimethyl orthoacetate; 3,4-diamino-5-methylbiphenyl;
With
acetic acid;
at 110 ℃;
for 18h;
With
ammonia;
In
water;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: nitric acid; acetic anhydride / 1.33 h / Cooling with ice
1.3: 4.5 h / 90 °C / Reflux
2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 20 h / 20 °C
4.1: acetic acid / 18 h / 110 °C
4.2: Cooling with ice
With
hydrogen; nitric acid; acetic anhydride; caesium carbonate; acetic acid;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
ethanol; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 20 h / 20 °C
2.1: acetic acid / 18 h / 110 °C
2.2: Cooling with ice
With
hydrogen; acetic acid;
palladium 10% on activated carbon;
In
ethanol; ethyl acetate;
