thiobutyric acid S-[4-(5-oxo-4-phenyl-2,5-dihydro-furan-3-yl)-phenyl] ester

Base Information

Chemical Name:thiobutyric acid S-[4-(5-oxo-4-phenyl-2,5-dihydro-furan-3-yl)-phenyl] ester
CAS No.:866336-10-9
Molecular Formula:C₂₀H₁₈O₃S
Molecular Weight:338.427
Hs Code.:

thiobutyric acid <i>S</i>-[4-(5-oxo-4-phenyl-2,5-dihydro-furan-3-yl)-phenyl] ester

Synonyms:thiobutyric acid S-[4-(5-oxo-4-phenyl-2,5-dihydro-furan-3-yl)-phenyl] ester

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Chemical Property of thiobutyric acid S-[4-(5-oxo-4-phenyl-2,5-dihydro-furan-3-yl)-phenyl] ester

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Technology Process of thiobutyric acid S-[4-(5-oxo-4-phenyl-2,5-dihydro-furan-3-yl)-phenyl] ester

There total 5 articles about thiobutyric acid S-[4-(5-oxo-4-phenyl-2,5-dihydro-furan-3-yl)-phenyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 4-(4-mercapto-phenyl)-3-phenyl-5H-furan-2-one

: 141-75-3
butyryl chloride

: 866336-10-9
thiobutyric acid S-[4-(5-oxo-4-phenyl-2,5-dihydro-furan-3-yl)-phenyl] ester

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 745820-44-4
4-(4-(methylsulfinyl)phenyl)-3-phenylfuran-2(5H)-one

: 866336-10-9
thiobutyric acid S-[4-(5-oxo-4-phenyl-2,5-dihydro-furan-3-yl)-phenyl] ester

Guidance literature:: Multi-step reaction with 2 steps

1: (CF₃CO)2O; 2,6-lutidine / acetonitrile / 1 h / -20 °C

2: pyridine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; 2,6-dimethylpyridine; trifluoroacetic anhydride; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2005.06.080

Reference yield:

: 98546-51-1
(4-thiomethoxyphenyl)boronic acid

: 866336-10-9
thiobutyric acid S-[4-(5-oxo-4-phenyl-2,5-dihydro-furan-3-yl)-phenyl] ester

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / PdCl₂(PPh₃)2; CsF; BnEt₃N⁽¹⁺⁾Cl^(1-) / 72 h

2: 71 percent / CsF; BnEt₃N⁽¹⁺⁾Cl^(1-); PdCl₂(PPh₃)2 / 72 h

3: 93 percent / m-CPBA / CH₂Cl₂ / 1 h / -30 °C

4: (CF₃CO)2O; 2,6-lutidine / acetonitrile / 1 h / -20 °C

5: pyridine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; 2,6-dimethylpyridine; bis-triphenylphosphine-palladium(II) chloride; N-benzyl-N,N,N-triethylammonium chloride; 3-chloro-benzenecarboperoxoic acid; cesium fluoride; trifluoroacetic anhydride; In dichloromethane; acetonitrile; 1: Suzuki coupling / 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2005.06.080