3-amino-6-fluoro-2-methyl-4-trimethylsilanyl ethynyl-benzoic acid methyl ester

Base Information

Chemical Name:3-amino-6-fluoro-2-methyl-4-trimethylsilanyl ethynyl-benzoic acid methyl ester
CAS No.:1609967-59-0
Molecular Formula:C₁₄H₁₈FNO₂Si
Molecular Weight:279.386
Hs Code.:

Synonyms:3-amino-6-fluoro-2-methyl-4-trimethylsilanyl ethynyl-benzoic acid methyl ester

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Chemical Property of 3-amino-6-fluoro-2-methyl-4-trimethylsilanyl ethynyl-benzoic acid methyl ester

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Technology Process of 3-amino-6-fluoro-2-methyl-4-trimethylsilanyl ethynyl-benzoic acid methyl ester

There total 2 articles about 3-amino-6-fluoro-2-methyl-4-trimethylsilanyl ethynyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1609967-58-9
3-amino-6-fluoro-4-iodo-2-methyl-benzoic acid methyl ester

: 1066-54-2
trimethylsilylacetylene

: 1609967-59-0
3-amino-6-fluoro-2-methyl-4-trimethylsilanyl ethynyl-benzoic acid methyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 110 ℃; for 8h;

Reference yield:

: 848678-60-4
3-amino-6-fluoro-2-methyl-benzoic acid methyl ester

: 1609967-59-0
3-amino-6-fluoro-2-methyl-4-trimethylsilanyl ethynyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-iodo-succinimide / acetic acid / 4 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / tetrahydrofuran / 8 h / 110 °C

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; triethylamine; In tetrahydrofuran; acetic acid;