N-(2-nitro-4-trifluoromethylphenylsulphonyl)piperidine-2-carboxylic acid

Base Information

• Chemical Name: N-(2-nitro-4-trifluoromethylphenylsulphonyl)piperidine-2-carboxylic acid
• CAS No.: 130178-58-4
• Molecular Formula: C₁₃H₁₃F₃N₂O₆S
• Molecular Weight: 382.317
• Mol file: 130178-58-4.mol

Synonyms:N-(2-nitro-4-trifluoromethylphenylsulphonyl)piperidine-2-carboxylic acid

Chemical Property of N-(2-nitro-4-trifluoromethylphenylsulphonyl)piperidine-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-nitro-4-trifluoromethylphenylsulphonyl)piperidine-2-carboxylic acid

There total 1 articles about N-(2-nitro-4-trifluoromethylphenylsulphonyl)piperidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-nitro-4-(trifluoromethyl)benzenesulfonyl chloride (837-95-6) + pipecolic Acid (4043-87-2,83680-83-5) → N-(2-nitro-4-trifluoromethylphenylsulphonyl)piperidine-2-carboxylic acid (130178-58-4)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; ethanol; for 1h; Heating;

DOI:10.1039/P19900001835

Reference yield:

N-(2-nitro-4-trifluoromethylphenylsulphonyl)piperidine-2-carboxylic acid (130178-58-4) → 1-(2-Nitro-4-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl chloride (130178-63-1)

Guidance literature:

With thionyl chloride; In benzene; Heating;

DOI:10.1039/P19900001835

Reference yield:

N-(2-nitro-4-trifluoromethylphenylsulphonyl)piperidine-2-carboxylic acid (130178-58-4) → 2-amino-N-(2-nitro-4-trifluoromethylphenylsulphonyl)piperidine (130178-76-6)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / benzene / Heating

2: CH₂Cl₂ / 1.5 h / Ambient temperature

3: conc. NH₃ / CH₂Cl₂ / 2 h

With ammonium hydroxide; thionyl chloride; In dichloromethane; benzene;

DOI:10.1039/P19900001835

upstream raw materials:

2-nitro-4-(trifluoromethyl)benzenesulfonyl chloride

pipecolic Acid

Downstream raw materials:

1-(2-Nitro-4-trifluoromethyl-benzenesulfonyl)-piperidine-2-carbonyl chloride

2-amino-N-(2-nitro-4-trifluoromethylphenylsulphonyl)piperidine

Trifluoro-methanesulfonate1-(2-nitro-4-trifluoromethyl-benzenesulfonyl)-2,3,4,5-tetrahydro-pyridinium;