9-methoxy-3-methyl-5-(4-chlorophenyl)-1H-[1,3]oxazino-[4,5-c]quinolin-1-one

Base Information

• Chemical Name: 9-methoxy-3-methyl-5-(4-chlorophenyl)-1H-[1,3]oxazino-[4,5-c]quinolin-1-one
• CAS No.: 1417806-27-9
• Molecular Formula: C₁₉H₁₃ClN₂O₃
• Molecular Weight: 352.777

Synonyms:9-methoxy-3-methyl-5-(4-chlorophenyl)-1H-[1,3]oxazino-[4,5-c]quinolin-1-one

Chemical Property of 9-methoxy-3-methyl-5-(4-chlorophenyl)-1H-[1,3]oxazino-[4,5-c]quinolin-1-one

Chemical Property:

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Technology Process of 9-methoxy-3-methyl-5-(4-chlorophenyl)-1H-[1,3]oxazino-[4,5-c]quinolin-1-one

There total 3 articles about 9-methoxy-3-methyl-5-(4-chlorophenyl)-1H-[1,3]oxazino-[4,5-c]quinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-amino-2-(4-chlorophenyl)-6-methoxyquinoline-4-carboxylic acid (1252645-48-9) + acetic anhydride (108-24-7) → 9-methoxy-3-methyl-5-(4-chlorophenyl)-1H-[1,3]oxazino-[4,5-c]quinolin-1-one (1417806-27-9)

Guidance literature:

for 5h; Reflux;

DOI:10.1007/s00044-012-0428-9

Reference yield:

5-methoxyisatine (39755-95-8) → 9-methoxy-3-methyl-5-(4-chlorophenyl)-1H-[1,3]oxazino-[4,5-c]quinolin-1-one (1417806-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water; tetrahydrofuran / 2.5 h / 85 °C / Reflux

2: 5 h / Reflux

With sodium hydroxide; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.ejmech.2018.04.015

Reference yield:

4-chlorophenacylamine hydrochloride (5467-71-0) → 9-methoxy-3-methyl-5-(4-chlorophenyl)-1H-[1,3]oxazino-[4,5-c]quinolin-1-one (1417806-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water; tetrahydrofuran / 2.5 h / 85 °C / Reflux

2: 5 h / Reflux

With sodium hydroxide; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.ejmech.2018.04.015

upstream raw materials:

3-amino-2-(4-chlorophenyl)-6-methoxyquinoline-4-carboxylic acid

acetic anhydride

5-methoxyisatine

4-chlorophenacylamine hydrochloride

Downstream raw materials:

3-methyl-9-methoxy-5-(4-chlorophenyl)-2-phenylpyrimido[4,5-c]quinolin-1(2H)-one

3-methyl-9-methoxy-5-(4-chlorophenyl)-2-(4-methoxyphenyl)pyrimido[4,5-c]quinolin-1(2H)-one

3-methyl-9-methoxy-5-(4-chlorophenyl)-2-(2,4-dimethoxyphenyl)pyrimido[4,5-c]quinolin-1(2H)-one

3-methyl-9-methoxy-5-(4-chlorophenyl)-2-(2,5-dimethoxyphenyl)pyrimido[4,5-c]quinolin-1(2H)-one

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