4-(1,2,4-triazolyl)-1-(1'-deuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)-1H-pyrimidin-2-one

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Chemical Name:4-(1,2,4-triazolyl)-1-(1'-deuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)-1H-pyrimidin-2-one
CAS No.:131131-99-2
Molecular Formula:C₂₇H₂₅N₅O₆
Molecular Weight:516.517
Hs Code.:

Synonyms:4-(1,2,4-triazolyl)-1-(1'-deuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)-1H-pyrimidin-2-one

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Chemical Property of 4-(1,2,4-triazolyl)-1-(1'-deuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)-1H-pyrimidin-2-one

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Technology Process of 4-(1,2,4-triazolyl)-1-(1'-deuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)-1H-pyrimidin-2-one

There total 8 articles about 4-(1,2,4-triazolyl)-1-(1'-deuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 288-88-0
1,2,4-Triazole

: 131131-96-9
1'-deuterio-3',5'-di-O-p-toluoyluridine

: 131131-99-2
4-(1,2,4-triazolyl)-1-(1'-deuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)-1H-pyrimidin-2-one

Guidance literature:: With trichlorophosphate; In triethylamine; for 3h; Ambient temperature;
DOI:10.1021/jo00004a040

Reference yield:

: 83159-91-5
3,5-di-O-(tert-butyldimethylsilyl)-2-deoxy-D-ribono-1,4-lactone

: 131131-99-2
4-(1,2,4-triazolyl)-1-(1'-deuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / diisobutylaluminium deuteride (Dibal-D) / hexane; diethyl ether; CH₂Cl₂ / 2 h / -78 °C

2: 1.) HCl, Ag₂CO₃, 2.) tetra-n-butylammonium fluoride / 1.) 15 min, room temp., 2.) 30 min, room temp., THF

3: 95 percent / 4-dimethylaminopyridine / pyridine / 2 h / 40 °C

4: 66 percent / HCl, HOAc

5: 84 percent / CHCl₃ / 2 h

6: 64 percent / POCl₃ / triethylamine / 3 h / Ambient temperature

With hydrogenchloride; dmap; tetrabutyl ammonium fluoride; diisobutylaluminium deuteride; acetic acid; silver carbonate; trichlorophosphate; In pyridine; diethyl ether; hexane; dichloromethane; chloroform; triethylamine;
DOI:10.1021/jo00004a040

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 131131-99-2
4-(1,2,4-triazolyl)-1-(1'-deuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / 4-dimethylaminopyridine / pyridine / 2 h / 40 °C

2: 66 percent / HCl, HOAc

3: 84 percent / CHCl₃ / 2 h

4: 64 percent / POCl₃ / triethylamine / 3 h / Ambient temperature

With hydrogenchloride; dmap; acetic acid; trichlorophosphate; In pyridine; chloroform; triethylamine;
DOI:10.1021/jo00004a040