N-[4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl]-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: N-[4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl]-2,2,2-trifluoroacetamide
• CAS No.: 944799-69-3
• Molecular Formula: C₁₅H₁₁F₃N₂O₄S₂
• Molecular Weight: 404.391
• Mol file: 944799-69-3.mol

Synonyms:N-[4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl]-2,2,2-trifluoroacetamide

Chemical Property of N-[4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl]-2,2,2-trifluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl]-2,2,2-trifluoroacetamide

There total 5 articles about N-[4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

→ N-[4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl]-2,2,2-trifluoroacetamide (944799-69-3)

Guidance literature:

Reference yield: 63.0%

4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-trifluoro acetamido-1,5-dihydropyrrolidone (608132-32-7) → N-[4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl]-2,2,2-trifluoroacetamide (944799-69-3)

Guidance literature:

4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-trifluoro acetamido-1,5-dihydropyrrolidone; With mercury(II) diacetate; trifluoroacetic acid; at 20 ℃; for 1h; Inert atmosphere;

With hydrogen sulfide; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1248/cpb.c12-00791

Reference yield:

C15H13S2N2O4F3 → N-[4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl]-2,2,2-trifluoroacetamide (944799-69-3)

Guidance literature:

With iodine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2007.04.017

upstream raw materials:

4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-trifluoro acetamido-1,5-dihydropyrrolidone

4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-amino-1,5-dihydropyrrolidone

4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-hydroxy-1,5-dihydropyrrolidone

Downstream raw materials:

6-amino-4-(2,4-dimethoxyphenyl)-4H-[1,2]dithioleheterocyclicpentene[4,3-b]-5-pyrrolidonecarboxylic acid ethyl ester

[4-(2,4-dimethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl]-carbamic acid allyl ester

[4-(2,4-dimethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl]-carbamic acid

C₂₂H₂₀N₂O₅S₂

Refernces

• 1、 -. "DITHIOLOPYRROLONE COMPOUNDS, THE PREPARATION AND THE USE THEREOF". Page/Page column 6. . Retrieved 2010/08/22.
• 2、 -. "NOVEL DITHIOLOPYRROLONES AND THEIR THERAPEUTICAL APPLICATIONS". Page/Page column 21. . Retrieved 2008/06/13.