diethyl (2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)ethyl)phosphonate

Base Information

Chemical Name:diethyl (2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)ethyl)phosphonate
CAS No.:1620085-48-4
Molecular Formula:C₂₅H₂₆FN₈O₃PS
Molecular Weight:568.571
Hs Code.:

Synonyms:diethyl (2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)ethyl)phosphonate

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Chemical Property of diethyl (2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)ethyl)phosphonate

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Technology Process of diethyl (2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)ethyl)phosphonate

There total 4 articles about diethyl (2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)ethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620085-45-1
7-ethynyl-2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidine

: 196302-98-4
2-azidoethylphosphonic acid diethyl ester

: 1620085-48-4
diethyl (2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)ethyl)phosphonate

Guidance literature:: With copper(II) sulfate penta hydrate; sodium L-ascorbate; In ethanol; water; at 20 ℃; for 72h; Microwave irradiation;
DOI:10.1016/j.bmcl.2014.05.080

Reference yield:

: 1629992-03-5
2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)-7-((trimethylsilyl)ethynyl)imidazo[1,2-a]pyrimidine

: 1620085-48-4
diethyl (2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)ethyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2: sodium L-ascorbate; copper(II) sulfate penta hydrate / ethanol; water / 72 h / 20 °C / Microwave irradiation

With copper(II) sulfate penta hydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmcl.2014.05.080

Reference yield:

: 5324-30-1
diethyl 2-bromoethylphosphonate

: 1620085-48-4
diethyl (2-(4-(2-(4-fluorophenyl)-3-(2-(methylthio)pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl)-1H-1,2,3-triazol-1-yl)ethyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium azide / tetrahydrofuran / 48 h / Reflux

2: sodium L-ascorbate; copper(II) sulfate penta hydrate / ethanol; water / 72 h / 20 °C / Microwave irradiation

With sodium azide; copper(II) sulfate penta hydrate; tetrabutylammomium bromide; sodium L-ascorbate; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmcl.2014.05.080