N-3-(6-nitro-1,3-benzothiazol-2-yl)-2-[(3,4,5-trifluorophenyl)amino]-3-pyridine carboxamide

Base Information

Chemical Name:N-3-(6-nitro-1,3-benzothiazol-2-yl)-2-[(3,4,5-trifluorophenyl)amino]-3-pyridine carboxamide
CAS No.:1350515-63-7
Molecular Formula:C₁₉H₁₀F₃N₅O₃S
Molecular Weight:445.381
Hs Code.:

Synonyms:N-3-(6-nitro-1,3-benzothiazol-2-yl)-2-[(3,4,5-trifluorophenyl)amino]-3-pyridine carboxamide

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Chemical Property of N-3-(6-nitro-1,3-benzothiazol-2-yl)-2-[(3,4,5-trifluorophenyl)amino]-3-pyridine carboxamide

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Technology Process of N-3-(6-nitro-1,3-benzothiazol-2-yl)-2-[(3,4,5-trifluorophenyl)amino]-3-pyridine carboxamide

There total 4 articles about N-3-(6-nitro-1,3-benzothiazol-2-yl)-2-[(3,4,5-trifluorophenyl)amino]-3-pyridine carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 6285-57-0
2-amino-6-nitrobenzothiazole

: 1350515-53-5
2-(3,4,5-trifluorophenylamino) nicotinic acid

: 1350515-63-7
N-3-(6-nitro-1,3-benzothiazol-2-yl)-2-[(3,4,5-trifluorophenyl)amino]-3-pyridine carboxamide

Guidance literature:: 2-(3,4,5-trifluorophenylamino) nicotinic acid; With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

2-amino-6-nitrobenzothiazole; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1016/j.bmc.2011.09.060

Reference yield:

: 163733-96-8
3,4,5-trifluoro aniline

: 1350515-63-7
N-3-(6-nitro-1,3-benzothiazol-2-yl)-2-[(3,4,5-trifluorophenyl)amino]-3-pyridine carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylene glycol / 6 h / 160 °C

2.1: sodium hydroxide / ethanol / 2 h / Reflux

3.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 8 h / 20 °C

With benzotriazol-1-ol; sodium hydroxide; In ethanol; ethylene glycol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.09.060

Reference yield:

: 1452-94-4
ethyl 2-chloronicotinate

: 1350515-63-7
N-3-(6-nitro-1,3-benzothiazol-2-yl)-2-[(3,4,5-trifluorophenyl)amino]-3-pyridine carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylene glycol / 6 h / 160 °C

2.1: sodium hydroxide / ethanol / 2 h / Reflux

3.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 8 h / 20 °C

With benzotriazol-1-ol; sodium hydroxide; In ethanol; ethylene glycol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.09.060