N-tert-butoxycarbonyl-4-[4-(4-fluorophenoxy)phenyl]-4-piperidinol

Base Information

• Chemical Name: N-tert-butoxycarbonyl-4-[4-(4-fluorophenoxy)phenyl]-4-piperidinol
• CAS No.: 224449-62-1
• Molecular Formula: C₂₂H₂₆FNO₄
• Molecular Weight: 387.451
• Mol file: 224449-62-1.mol

Synonyms:N-tert-butoxycarbonyl-4-[4-(4-fluorophenoxy)phenyl]-4-piperidinol

Chemical Property of N-tert-butoxycarbonyl-4-[4-(4-fluorophenoxy)phenyl]-4-piperidinol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butoxycarbonyl-4-[4-(4-fluorophenoxy)phenyl]-4-piperidinol

There total 1 articles about N-tert-butoxycarbonyl-4-[4-(4-fluorophenoxy)phenyl]-4-piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

1-bromo-4-(4-fluorophenoxy) benzene (55102-99-3) + ammonium chloride + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → N-tert-butoxycarbonyl-4-[4-(4-fluorophenoxy)phenyl]-4-piperidinol (224449-62-1)

Guidance literature:

In tetrahydrofuran;

Reference yield: 97.0%

N-tert-butoxycarbonyl-4-[4-(4-fluorophenoxy)phenyl]-4-piperidinol (224449-62-1) → 4-[4-(4-fluorophenoxy)phenyl]-1,2,3,6-tetrahydropyridine (224449-68-7)

Guidance literature:

With sodium hydroxide; trifluoroacetic acid; In dichloromethane;

upstream raw materials:

1-bromo-4-(4-fluorophenoxy) benzene

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

4-[4-(4-fluorophenoxy)phenyl]-1,2,3,6-tetrahydropyridine