2-(benzhydrylidene-amino)-3-(5-iodo-2-isopropoxy-phenyl)-propionic acid tert-butyl ester

Base Information

Chemical Name:2-(benzhydrylidene-amino)-3-(5-iodo-2-isopropoxy-phenyl)-propionic acid tert-butyl ester
CAS No.:861099-85-6
Molecular Formula:C₂₉H₃₂INO₃
Molecular Weight:569.482
Hs Code.:

2-(benzhydrylidene-amino)-3-(5-iodo-2-isopropoxy-phenyl)-propionic acid <i>tert</i>-butyl ester

Synonyms:2-(benzhydrylidene-amino)-3-(5-iodo-2-isopropoxy-phenyl)-propionic acid tert-butyl ester

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Chemical Property of 2-(benzhydrylidene-amino)-3-(5-iodo-2-isopropoxy-phenyl)-propionic acid tert-butyl ester

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Technology Process of 2-(benzhydrylidene-amino)-3-(5-iodo-2-isopropoxy-phenyl)-propionic acid tert-butyl ester

There total 1 articles about 2-(benzhydrylidene-amino)-3-(5-iodo-2-isopropoxy-phenyl)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 2-isopropyloxy-5-iodo-benzyl bromide

: 81477-94-3
N-(diphenylmethylene)glycine tert-butyl ester

: 861099-85-6
2-(benzhydrylidene-amino)-3-(5-iodo-2-isopropoxy-phenyl)-propionic acid tert-butyl ester

Guidance literature:: With cesium hydroxide; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide; In dichloromethane; water; at -50 ℃;
DOI:10.1021/ol050949w

Reference yield: 61.0%

: 861099-85-6
2-(benzhydrylidene-amino)-3-(5-iodo-2-isopropoxy-phenyl)-propionic acid tert-butyl ester

: 2-amino-3-(5-iodo-2-isopropoxy-phenyl)-propionic acid tert-butyl ester

Guidance literature:: With citric acid; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ol050949w

Reference yield:

: 861099-85-6
2-(benzhydrylidene-amino)-3-(5-iodo-2-isopropoxy-phenyl)-propionic acid tert-butyl ester

: 861099-92-5
(8S,11S,14S)-11-((R)-3-Benzyloxycarbonyl-2,2-dimethyl-oxazolidin-5-ylmethyl)-14-tert-butoxycarbonylamino-5,17-diisopropoxy-10,13-dioxo-9,12-diaza-tricyclo[14.3.1.1^2,6]henicosa-1⁽¹⁹⁾,2,4,6⁽²¹⁾,16⁽²⁰⁾,17-hexaene-8-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 61 percent / aq. citric acid / tetrahydrofuran / 20 °C

2: 100 percent / aq. HCl / CHCl₃ / 20 °C

3: 77 percent / AcBr / 0 °C

4: 95 percent / K₂CO₃ / dioxane; H₂O

5: 99 percent / aq. LiOH / dioxane

6: 81 percent / EDC; HOBt / CH₂Cl₂ / 20 °C

7: aq. LiOH / dioxane / 20 °C

8: EDC; HOBt / CH₂Cl₂ / 20 °C

9: 50 percent / K₂CO₃; TBAF / [3-(1,3-(MeO)2-C₆H₃-)C₆H₄-Cy₂P]2PdCl₂ / toluene; H₂O / 0.5 h / 110 °C / microwave irradiation

With hydrogenchloride; lithium hydroxide; Acetyl bromide; tetrabutyl ammonium fluoride; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; citric acid; [3-(1,3-(MeO)2-C₆H₃-)C₆H₄-Cy₂P]2PdCl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; toluene; 9: Suzuki-Miyaura reaction;
DOI:10.1021/ol050949w