tert-butyl[((2E)-2-{(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-2-[(trimethylsilyl)methyl]cyclohex-2-en-1-ylidene}ethyl)oxy]diphenylsilane

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Chemical Name:tert-butyl[((2E)-2-{(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-2-[(trimethylsilyl)methyl]cyclohex-2-en-1-ylidene}ethyl)oxy]diphenylsilane
CAS No.:905976-86-5
Molecular Formula:C₃₄H₅₄O₂Si₃
Molecular Weight:579.058
Hs Code.:

Synonyms:tert-butyl[((2E)-2-{(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-2-[(trimethylsilyl)methyl]cyclohex-2-en-1-ylidene}ethyl)oxy]diphenylsilane

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Chemical Property of tert-butyl[((2E)-2-{(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-2-[(trimethylsilyl)methyl]cyclohex-2-en-1-ylidene}ethyl)oxy]diphenylsilane

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Technology Process of tert-butyl[((2E)-2-{(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-2-[(trimethylsilyl)methyl]cyclohex-2-en-1-ylidene}ethyl)oxy]diphenylsilane

There total 9 articles about tert-butyl[((2E)-2-{(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-2-[(trimethylsilyl)methyl]cyclohex-2-en-1-ylidene}ethyl)oxy]diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 905976-90-1
(4S,6E)-4-{[tert-butyl(dimethyl)silyl]oxy}-6-(2-{[tert-butyl(diphenyl)silyl]oxy}ethylidene)cyclohex-1-en-1-yl trifluoromethanesulfonate

: 13170-43-9
(trimethylsilyl)methylmagnesium chloride

: 905976-86-5
tert-butyl[((2E)-2-{(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-2-[(trimethylsilyl)methyl]cyclohex-2-en-1-ylidene}ethyl)oxy]diphenylsilane

Guidance literature:: With lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jo060516m

Reference yield:

: 905976-87-6
(2E,4S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(2-{[tert-butyl(diphenyl)silyl]oxy}ethylidene)cyclohexanone

: 905976-86-5
tert-butyl[((2E)-2-{(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-2-[(trimethylsilyl)methyl]cyclohex-2-en-1-ylidene}ethyl)oxy]diphenylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 60 percent / tetrahydrofuran; hexane / 3.5 h / -40 °C

2.1: 98 percent / LiCl / (Ph₃P)4Pd / tetrahydrofuran / 2 h / 20 °C

With lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane;
DOI:10.1021/jo060516m

Reference yield:

: 905976-88-7
(4S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(2-{[tert-butyl(diphenyl)silyl]oxy}-1-hydroxyethyl)cyclohexanone

: 905976-86-5
tert-butyl[((2E)-2-{(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-2-[(trimethylsilyl)methyl]cyclohex-2-en-1-ylidene}ethyl)oxy]diphenylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 87 percent / Et₃N / CH₂Cl₂ / 15 h / 20 °C

2.1: 64 percent / DBU / tetrahydrofuran / 3 h / 20 °C

3.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 60 percent / tetrahydrofuran; hexane / 3.5 h / -40 °C

4.1: 98 percent / LiCl / (Ph₃P)4Pd / tetrahydrofuran / 2 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo060516m