2-(4-fluorobenzylthio)-1-(2-((1-(2-(diethylamino)-ethyl)-3-phenyl-1H-pyrazol-5-yl)methoxy)ethyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Chemical Name:2-(4-fluorobenzylthio)-1-(2-((1-(2-(diethylamino)-ethyl)-3-phenyl-1H-pyrazol-5-yl)methoxy)ethyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one
CAS No.:1357157-57-3
Molecular Formula:C₃₂H₃₈FN₅O₂S
Molecular Weight:575.75
Hs Code.:

Synonyms:2-(4-fluorobenzylthio)-1-(2-((1-(2-(diethylamino)-ethyl)-3-phenyl-1H-pyrazol-5-yl)methoxy)ethyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Chemical Property of 2-(4-fluorobenzylthio)-1-(2-((1-(2-(diethylamino)-ethyl)-3-phenyl-1H-pyrazol-5-yl)methoxy)ethyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Technology Process of 2-(4-fluorobenzylthio)-1-(2-((1-(2-(diethylamino)-ethyl)-3-phenyl-1H-pyrazol-5-yl)methoxy)ethyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

There total 11 articles about 2-(4-fluorobenzylthio)-1-(2-((1-(2-(diethylamino)-ethyl)-3-phenyl-1H-pyrazol-5-yl)methoxy)ethyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1357158-11-2
2-((1-(2-(diethylamino)ethyl)-3-phenyl-1H-pyrazol-5-yl)methoxy)ethyl methanesulfonate

: 451487-18-6
2-[(4-fluorobenzyl)sulfanyl]-1,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one

: 1357157-57-3
2-(4-fluorobenzylthio)-1-(2-((1-(2-(diethylamino)-ethyl)-3-phenyl-1H-pyrazol-5-yl)methoxy)ethyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1002/cjoc.201180354

Reference yield:

: 1101861-35-1
ethyl 3-phenyl-1-(2-bromoethyl)-1H-pyrazole-5-carboxylate

: 1357157-57-3
2-(4-fluorobenzylthio)-1-(2-((1-(2-(diethylamino)-ethyl)-3-phenyl-1H-pyrazol-5-yl)methoxy)ethyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; potassium iodide / acetonitrile / 5.17 h / 20 °C / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

3.1: potassium / Inert atmosphere

3.2: 0.17 h / Inert atmosphere

3.3: 3 h / Inert atmosphere; Reflux

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

5.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling

6.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

With lithium aluminium tetrahydride; potassium; potassium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/cjoc.201180354

Reference yield:

: 1357157-76-6
ethyl 1-(2-(diethylamino)ethyl)-3-phenyl-1H-pyrazole-5-carboxylate

: 1357157-57-3
2-(4-fluorobenzylthio)-1-(2-((1-(2-(diethylamino)-ethyl)-3-phenyl-1H-pyrazol-5-yl)methoxy)ethyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

2.1: potassium / Inert atmosphere

2.2: 0.17 h / Inert atmosphere

2.3: 3 h / Inert atmosphere; Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

4.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

With lithium aluminium tetrahydride; potassium; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cjoc.201180354