(+/-)-2-{[(tert-butyldimethylsilyl)oxy](2-nitrophenyl)methyl}prop-2-enoic acid

Base Information

Chemical Name:(+/-)-2-{[(tert-butyldimethylsilyl)oxy](2-nitrophenyl)methyl}prop-2-enoic acid
CAS No.:1038432-33-5
Molecular Formula:C₁₆H₂₃NO₅Si
Molecular Weight:337.448
Hs Code.:

Synonyms:(+/-)-2-{[(tert-butyldimethylsilyl)oxy](2-nitrophenyl)methyl}prop-2-enoic acid

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Chemical Property of (+/-)-2-{[(tert-butyldimethylsilyl)oxy](2-nitrophenyl)methyl}prop-2-enoic acid

Chemical Property:

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Technology Process of (+/-)-2-{[(tert-butyldimethylsilyl)oxy](2-nitrophenyl)methyl}prop-2-enoic acid

There total 3 articles about (+/-)-2-{[(tert-butyldimethylsilyl)oxy](2-nitrophenyl)methyl}prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1038432-26-6
C₁₇H₂₅NO₅Si

: 1038432-33-5
(+/-)-2-{[(tert-butyldimethylsilyl)oxy](2-nitrophenyl)methyl}prop-2-enoic acid

Guidance literature:: With lithium hydroxide; In acetonitrile; at 50 - 60 ℃;
DOI:10.1016/j.tetlet.2008.04.040

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 1038432-33-5
(+/-)-2-{[(tert-butyldimethylsilyl)oxy](2-nitrophenyl)methyl}prop-2-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / 30 °C / Sonication

2: 1H-imidazole; dimethyl sulfoxide / 20 °C / Inert atmosphere

3: water; lithium hydroxide / acetonitrile / 4 h / 50 - 60 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; water; dimethyl sulfoxide; lithium hydroxide; In acetonitrile; 1: Morita-Baylis-Hillman reaction;
DOI:10.1590/S0103-50532011000800022

Reference yield:

: 159763-36-7
3-hydroxy-2-methylene-3-(2-nitrophenyl)propanoic acid methyl ester

: 1038432-33-5
(+/-)-2-{[(tert-butyldimethylsilyl)oxy](2-nitrophenyl)methyl}prop-2-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole; dimethyl sulfoxide / 20 °C / Inert atmosphere

2: water; lithium hydroxide / acetonitrile / 4 h / 50 - 60 °C

With 1H-imidazole; water; dimethyl sulfoxide; lithium hydroxide; In acetonitrile;
DOI:10.1590/S0103-50532011000800022