N-(pyridin-3-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidine-8-carboxamide

Base Information

Chemical Name:N-(pyridin-3-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidine-8-carboxamide
CAS No.:1431647-28-7
Molecular Formula:C₁₉H₁₂F₃N₅O
Molecular Weight:383.332
Hs Code.:

Synonyms:N-(pyridin-3-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidine-8-carboxamide

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Chemical Property of N-(pyridin-3-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidine-8-carboxamide

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Technology Process of N-(pyridin-3-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidine-8-carboxamide

There total 6 articles about N-(pyridin-3-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 462-08-8
pyridin-3-ylamine

: 1431654-64-6
2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidine-8-carboxylic acid

: 1431647-28-7
N-(pyridin-3-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidine-8-carboxamide

Guidance literature:: 2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidine-8-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 0.5h;

pyridin-3-ylamine; With pyridine; In water; at 20 ℃; for 3h;

Reference yield: 28.0%

: 462-08-8
pyridin-3-ylamine

: C₁₄H₇ClF₃N₃O

: 1431647-28-7
N-(pyridin-3-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidine-8-carboxamide

Guidance literature:: With pyridine; at 20 ℃; for 2h;

Reference yield:

: 222292-69-5
ethyl 2-oxo-1,2-dihydroimidazo[1,5-a]pyrimidine-8-carboxylate

: 1431647-28-7
N-(pyridin-3-yl)-2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidine-8-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 1 h / 120 °C

2.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 1 h / 100 °C

3.1: water; potassium hydroxide / methanol / 1 h / Reflux

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h

4.2: 3 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; water; caesium carbonate; N,N-dimethyl-formamide; potassium hydroxide; trichlorophosphate; In 1,4-dioxane; methanol; dichloromethane;