Boc-Phe-Glu(OBzl)-Pro-Ile-Pro-Glu(OBzl)-Tyr(Cl₂Bzl)-Tyr(Cl₂Bzl)-OH

Base Information

• Chemical Name: Boc-Phe-Glu(OBzl)-Pro-Ile-Pro-Glu(OBzl)-Tyr(Cl₂Bzl)-Tyr(Cl₂Bzl)-OH
• CAS No.: 146843-76-7
• Molecular Formula: C₈₆H₉₆Cl₄N₈O₁₇
• Molecular Weight: 1655.56
• Mol file: 146843-76-7.mol

Synonyms:Boc-Phe-Glu(OBzl)-Pro-Ile-Pro-Glu(OBzl)-Tyr(Cl₂Bzl)-Tyr(Cl₂Bzl)-OH

Chemical Property of Boc-Phe-Glu(OBzl)-Pro-Ile-Pro-Glu(OBzl)-Tyr(Cl₂Bzl)-Tyr(Cl₂Bzl)-OH

Chemical Property:

Purity/Quality:

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Technology Process of Boc-Phe-Glu(OBzl)-Pro-Ile-Pro-Glu(OBzl)-Tyr(Cl₂Bzl)-Tyr(Cl₂Bzl)-OH

There total 1 articles about Boc-Phe-Glu(OBzl)-Pro-Ile-Pro-Glu(OBzl)-Tyr(Cl₂Bzl)-Tyr(Cl₂Bzl)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Boc-Phe-Glu(OBzl)-Pro-Ile-Pro-Glu(OBzl)-Tyr(Cl2Bzl)-Tyr(Cl2Bzl)-OPac → Boc-Phe-Glu(OBzl)-Pro-Ile-Pro-Glu(OBzl)-Tyr(Cl2Bzl)-Tyr(Cl2Bzl)-OH (146843-76-7)

Guidance literature:

With acetic acid; zinc; for 2h; Ambient temperature;

DOI:10.1248/cpb.44.1344

Reference yield: 100.0%

Boc-Phe-Glu(OBzl)-Pro-Ile-Pro-Glu(OBzl)-Tyr(Cl2Bzl)-Tyr(Cl2Bzl)-OH (146843-76-7) + (S)-2-Amino-4-methyl-pentanoic acid 2,2,2-trichloro-ethyl ester; compound with toluene-4-sulfonic acid → Boc-Phe-Glu(OBzl)-Pro-Ile-Pro-Glu(OBzl)-Tyr(Cl2Bzl)-Tyr(Cl2Bzl)-Leu-OTce

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; 1.) -8 deg C, 1 h, 2.) 5 deg C, overnight;

DOI:10.1248/cpb.44.1344

Reference yield:

Boc-Phe-Glu(OBzl)-Pro-Ile-Pro-Glu(OBzl)-Tyr(Cl2Bzl)-Tyr(Cl2Bzl)-OH (146843-76-7) → Phe-Glu(OBzl)-Pro-Ile-Pro-Glu(OBzl)-Tyr(Cl2Bzl)-Tyr(Cl2Bzl)-OH hydrochloride

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 4 ℃; for 1h;

DOI:10.1248/cpb.44.1344