[7-(4-fluoro-phenyl)-4,7-dioxo-6-pyridin-4-yl-heptyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [7-(4-fluoro-phenyl)-4,7-dioxo-6-pyridin-4-yl-heptyl]-carbamic acid benzyl ester
• CAS No.: 888318-99-8
• Molecular Formula: C₂₆H₂₅FN₂O₄
• Molecular Weight: 448.494

Synonyms:[7-(4-fluoro-phenyl)-4,7-dioxo-6-pyridin-4-yl-heptyl]-carbamic acid benzyl ester

Chemical Property of [7-(4-fluoro-phenyl)-4,7-dioxo-6-pyridin-4-yl-heptyl]-carbamic acid benzyl ester

Chemical Property:

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Technology Process of [7-(4-fluoro-phenyl)-4,7-dioxo-6-pyridin-4-yl-heptyl]-carbamic acid benzyl ester

There total 5 articles about [7-(4-fluoro-phenyl)-4,7-dioxo-6-pyridin-4-yl-heptyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(benzyloxycarbonylamino)butyric acid (5105-78-2) → [7-(4-fluoro-phenyl)-4,7-dioxo-6-pyridin-4-yl-heptyl]-carbamic acid benzyl ester (888318-99-8)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide

2: n-BuLi / tetrahydrofuran / -78 °C

3: K₂CO₃ / acetonitrile

4: thiazolium iodide; Et₃N / ethanol / Heating

With n-butyllithium; thiazolium iodide; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile; 3: Horner-Emmons reaction;

DOI:10.1016/j.bmcl.2006.01.041

Reference yield:

(5-benzyloxycarbonylamino-2-oxo-pentyl)-phosphonic acid dimethyl ester (888318-97-6) → [7-(4-fluoro-phenyl)-4,7-dioxo-6-pyridin-4-yl-heptyl]-carbamic acid benzyl ester (888318-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile

2: thiazolium iodide; Et₃N / ethanol / Heating

With thiazolium iodide; potassium carbonate; triethylamine; In ethanol; acetonitrile; 1: Horner-Emmons reaction;

DOI:10.1016/j.bmcl.2006.01.041

Reference yield:

pyridine-4-carbaldehyde (872-85-5) → [7-(4-fluoro-phenyl)-4,7-dioxo-6-pyridin-4-yl-heptyl]-carbamic acid benzyl ester (888318-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile

2: thiazolium iodide; Et₃N / ethanol / Heating

With thiazolium iodide; potassium carbonate; triethylamine; In ethanol; acetonitrile; 1: Horner-Emmons reaction;

DOI:10.1016/j.bmcl.2006.01.041

upstream raw materials:

4-fluorobenzaldehyde

(5-benzyloxycarbonylamino-2-oxo-pentyl)-phosphonic acid dimethyl ester

pyridine-4-carbaldehyde

4-(benzyloxycarbonylamino)butyric acid

Downstream raw materials:

{3-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-propyl}-methyl-amine

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