N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucine

Base Information

• Chemical Name: N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucine
• CAS No.: 1064622-37-2
• Molecular Formula: C₁₇H₁₈BrF₄NO₃
• Molecular Weight: 440.232

Synonyms:N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucine

Chemical Property of N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucine

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Technology Process of N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucine

There total 1 articles about N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H32BrF4NO2Si (1064622-39-4) → N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucine (1064622-37-2)

Guidance literature:

With sodium chlorite; phosphoric acid; 2-Methyl-1-butene; In water; tert-butyl alcohol; at 0 - 20 ℃; for 1.5h;

Reference yield:

(2R)-2-Amino-3-(tritylsulfanyl)propanamide (166737-85-5) + N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucine (1064622-37-2) → N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucyl-S-trityl-L-cysteinamide (1064622-45-2)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; triethylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucine (1064622-37-2) + S-trityl-L-cysteine methyl ether (58885-35-1,115545-85-2) → methyl N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucyl-S-trityl-L-cysteinate (1064622-92-9)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; triethylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃;

upstream raw materials:

C₂₃H₃₂BrF₄NO₂Si

Downstream raw materials:

N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucyl-S-trityl-L-cysteinamide

methyl N-[(1R)-1-(4-bromophenyl)-4-hydroxy-1-(trifluoromethyl)but-2-yn-1-yl]-4-fluoro-L-leucyl-S-trityl-L-cysteinate

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