<3(S,R),4(S,R),5(S,R)>-5-(4-methoxyphenyl)-4-methyl-3-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>tetrahydrofuran-2-one

Base Information

Chemical Name:<3(S,R),4(S,R),5(S,R)>-5-(4-methoxyphenyl)-4-methyl-3-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>tetrahydrofuran-2-one
CAS No.:131490-76-1
Molecular Formula:C₁₈H₂₇NO₅Si
Molecular Weight:365.502
Hs Code.:

Synonyms:<3(S,R),4(S,R),5(S,R)>-5-(4-methoxyphenyl)-4-methyl-3-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>tetrahydrofuran-2-one

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Chemical Property of <3(S,R),4(S,R),5(S,R)>-5-(4-methoxyphenyl)-4-methyl-3-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>tetrahydrofuran-2-one

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Technology Process of <3(S,R),4(S,R),5(S,R)>-5-(4-methoxyphenyl)-4-methyl-3-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>tetrahydrofuran-2-one

There total 5 articles about <3(S,R),4(S,R),5(S,R)>-5-(4-methoxyphenyl)-4-methyl-3-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>tetrahydrofuran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 131490-86-3
<3(S,R),4(S,R),5(S,R)>-3-amino-5-(4-methoxyphenyl)-4-methyltetrahydrofuran-2-one hydrogen 4-toluenesulfonate

: 121750-77-4
2-(trimethylsilyl)ethyl-p-nitrophenyl carbonate

: 131490-76-1
<3(S,R),4(S,R),5(S,R)>-5-(4-methoxyphenyl)-4-methyl-3-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>tetrahydrofuran-2-one

Guidance literature:: With triethylamine; In tetrahydrofuran; at 25 ℃; for 48h;
DOI:10.1021/jo00005a042

Reference yield:

: 88155-33-3
<2(S,R),3(S,R),4(S,R)>-2-amino-4-hydroxy-4-(4-methoxyphenyl)-3-methylbutanoic acid

: 131490-76-1
<3(S,R),4(S,R),5(S,R)>-5-(4-methoxyphenyl)-4-methyl-3-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>tetrahydrofuran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 4-toluenesulfonic acid / methanol / 0.08 h

2: 64 percent / Et₃N / tetrahydrofuran / 48 h / 25 °C

With toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jo00005a042

Reference yield:

: 88072-83-7
<5(S,R),4(S,R)>-5-(4-methoxyphenyl)-4-methyl-N-tert-butylisoxazolinecarboxamide

: 131490-76-1
<3(S,R),4(S,R),5(S,R)>-5-(4-methoxyphenyl)-4-methyl-3-<<<2-(trimethylsilyl)ethoxy>carbonyl>amino>tetrahydrofuran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 47 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 1.) -78 deg C, 1 h 2.) 4 deg C, 18 h

2: 65 percent / aq. NaOH / 48 h

3: 4-toluenesulfonic acid / methanol / 0.08 h

4: 64 percent / Et₃N / tetrahydrofuran / 48 h / 25 °C

With sodium hydroxide; toluene-4-sulfonic acid; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jo00005a042