1-(4-(2-(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-ylamino)ethyl)piperazin-1-yl)ethanone hydrochloride

Base Information

Chemical Name:1-(4-(2-(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-ylamino)ethyl)piperazin-1-yl)ethanone hydrochloride
CAS No.:1616793-41-9
Molecular Formula:C₁₇H₂₂Cl₂N₆O*ClH
Molecular Weight:433.768
Hs Code.:

Synonyms:1-(4-(2-(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-ylamino)ethyl)piperazin-1-yl)ethanone hydrochloride

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Chemical Property of 1-(4-(2-(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-ylamino)ethyl)piperazin-1-yl)ethanone hydrochloride

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Technology Process of 1-(4-(2-(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-ylamino)ethyl)piperazin-1-yl)ethanone hydrochloride

There total 5 articles about 1-(4-(2-(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-ylamino)ethyl)piperazin-1-yl)ethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1616794-10-5
1-(4-(2-(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-ylamino)ethyl)piperazin-1-yl)ethanone

: 1616793-41-9
1-(4-(2-(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-ylamino)ethyl)piperazin-1-yl)ethanone hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; acetone; at 20 ℃; for 0.5h;

Reference yield:

: 1617536-31-8
tert-butyl 2-(4-acetylpiperazin-1-yl)ethyl(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)carbamate

: 1616793-41-9
1-(4-(2-(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-ylamino)ethyl)piperazin-1-yl)ethanone hydrochloride

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm501920g

Reference yield:

: 1617536-29-4
tert-butyl 2-(4-acetylpiperazin-1-yl)ethylcarbamate

: 1616793-41-9
1-(4-(2-(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-ylamino)ethyl)piperazin-1-yl)ethanone hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium phosphate / toluene / 48 h / 110 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.67 h / 0 - 20 °C / Inert atmosphere

2.2: 20 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: hydrogenchloride / acetone; diethyl ether / 0.5 h / 20 °C

With hydrogenchloride; potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; acetone; toluene;