3-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-benzoic acid

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Chemical Name:3-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-benzoic acid
CAS No.:1263776-13-1
Molecular Formula:C₁₉H₂₀F₃N₃O₃
Molecular Weight:395.381
Hs Code.:

Synonyms:3-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-benzoic acid

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Chemical Property of 3-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-benzoic acid

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Technology Process of 3-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-benzoic acid

There total 6 articles about 3-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263776-11-9
3-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-benzoic acid ethyl ester

: 1263776-13-1
3-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-benzoic acid

Guidance literature:: 3-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-benzoic acid ethyl ester; With water; sodium hydroxide; In methanol; at 20 ℃; for 4h;

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;

With hydrogenchloride; In water; ethyl acetate; pH=1 - 2;

Reference yield:

: 782493-24-7
ethyl tert-butyl 4-(3-(ethoxycarbonyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

: 1263776-13-1
3-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium on activated charcoal / ethanol

2.1: hydrogenchloride / 1,4-dioxane / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 20 °C

4.1: sodium hydroxide; water / methanol / 4 h / 20 °C

4.2: 20 °C

4.3: pH 1 - 2

With hydrogenchloride; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1263776-13-1
3-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 20 - 110 °C

2.1: hydrogen / palladium on activated charcoal / ethanol

3.1: hydrogenchloride / 1,4-dioxane / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 20 °C

5.1: sodium hydroxide; water / methanol / 4 h / 20 °C

5.2: 20 °C

5.3: pH 1 - 2

With hydrogenchloride; water; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;