1-ethyl-4-(2-chloro-3-(6-ethyl-2-hydroxymorpholin-4-yl)-4-methylsulfonylbenzoyl)-5-hydroxypyrazole

Base Information

• Chemical Name: 1-ethyl-4-(2-chloro-3-(6-ethyl-2-hydroxymorpholin-4-yl)-4-methylsulfonylbenzoyl)-5-hydroxypyrazole
• CAS No.: 214057-43-9
• Molecular Formula: C₁₉H₂₄ClN₃O₆S
• Molecular Weight: 457.935

Synonyms:1-ethyl-4-(2-chloro-3-(6-ethyl-2-hydroxymorpholin-4-yl)-4-methylsulfonylbenzoyl)-5-hydroxypyrazole

Chemical Property of 1-ethyl-4-(2-chloro-3-(6-ethyl-2-hydroxymorpholin-4-yl)-4-methylsulfonylbenzoyl)-5-hydroxypyrazole

Chemical Property:

Purity/Quality:

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Technology Process of 1-ethyl-4-(2-chloro-3-(6-ethyl-2-hydroxymorpholin-4-yl)-4-methylsulfonylbenzoyl)-5-hydroxypyrazole

There total 2 articles about 1-ethyl-4-(2-chloro-3-(6-ethyl-2-hydroxymorpholin-4-yl)-4-methylsulfonylbenzoyl)-5-hydroxypyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[2-chloro-3-(1-ethyl-5-hydroxy-1H-pyrazole-4-carbonyl)-6-methanesulfonyl-phenyl]-6-ethyl-morpholin-2-one (752993-06-9) → 1-ethyl-4-(2-chloro-3-(6-ethyl-2-hydroxymorpholin-4-yl)-4-methylsulfonylbenzoyl)-5-hydroxypyrazole (214057-43-9)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 0.5h;

DOI:10.2533/000942903777678579

Reference yield:

1-Ethyl-4-(2-chloro-3-(2-hydroxybutylamino)-4-methylsulfonylbenzoyl)-5-hydroxypyrazole (214057-34-8) → 1-ethyl-4-(2-chloro-3-(6-ethyl-2-hydroxymorpholin-4-yl)-4-methylsulfonylbenzoyl)-5-hydroxypyrazole (214057-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene; H₂O / 90 - 110 °C

2: diisobutyl aluminum hydride / CH₂Cl₂ / 0.5 h / -78 °C

With diisobutylaluminium hydride; In dichloromethane; water; toluene;

DOI:10.2533/000942903777678579

Reference yield:

1-ethyl-4-(2-chloro-3-(6-ethyl-2-hydroxymorpholin-4-yl)-4-methylsulfonylbenzoyl)-5-hydroxypyrazole (214057-43-9) → 1-Ethyl-4-(2-chloro-3-(2-ethylmorpholin-4-yl)-4-methylsulfonylbenzoyl)-5-hydroxypyrazole

Guidance literature:

With triethylsilane; trifluoroacetic acid; at 20 ℃; for 0.5h;

DOI:10.2533/000942903777678579

upstream raw materials:

4-[2-chloro-3-(1-ethyl-5-hydroxy-1H-pyrazole-4-carbonyl)-6-methanesulfonyl-phenyl]-6-ethyl-morpholin-2-one

1-Ethyl-4-(2-chloro-3-(2-hydroxybutylamino)-4-methylsulfonylbenzoyl)-5-hydroxypyrazole

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