Technology Process of Pyoc-Phe-Leu-Leu-OtBu
There total 5 articles about Pyoc-Phe-Leu-Leu-OtBu which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
2: acetonitrile; H2O / 1) pH 9.5; 2) pH 6
3: 1) triethylamine, chloroformic acid ethylester / 1) CH2Cl2, -15 deg C; 2 h, 0 deg C; 2) -15 deg C
4: 88 percent / trifluoroacetic acid / CH2Cl2 / 0 °C
5: 95 percent / DCC/ HO-SU / CH2Cl2
With
1-hydroxy-pyrrolidine-2,5-dione; chloroformic acid ethyl ester; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) triethylamine, chloroformic acid ethylester / 1) CH2Cl2, -15 deg C; 2 h, 0 deg C; 2) -15 deg C
2: 88 percent / trifluoroacetic acid / CH2Cl2 / 0 °C
3: 95 percent / DCC/ HO-SU / CH2Cl2
With
1-hydroxy-pyrrolidine-2,5-dione; chloroformic acid ethyl ester; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
dichloromethane;
