4-(5-(1-(7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)ethyl)pyrazolo[1,5-a]pyridin-3-yl)benzamide

Base Information

Chemical Name:4-(5-(1-(7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)ethyl)pyrazolo[1,5-a]pyridin-3-yl)benzamide
CAS No.:1610610-83-7
Molecular Formula:C₂₄H₁₉FN₄O₃
Molecular Weight:430.438
Hs Code.:

Synonyms:4-(5-(1-(7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)ethyl)pyrazolo[1,5-a]pyridin-3-yl)benzamide

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Chemical Property of 4-(5-(1-(7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)ethyl)pyrazolo[1,5-a]pyridin-3-yl)benzamide

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Technology Process of 4-(5-(1-(7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)ethyl)pyrazolo[1,5-a]pyridin-3-yl)benzamide

There total 6 articles about 4-(5-(1-(7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)ethyl)pyrazolo[1,5-a]pyridin-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1610612-24-2
4-(1-(3-bromopyrazolo[1,5-a]pyridin-5-yl)ethyl)-7-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one

: 123088-59-5
4-carbamoylphenylboronic acid

: 1610610-83-7
4-(5-(1-(7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)ethyl)pyrazolo[1,5-a]pyridin-3-yl)benzamide

Guidance literature:: With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris-(o-tolyl)phosphine; In ethanol; water; toluene; at 90 ℃; for 7h;

Reference yield:

: 137472-06-1
2-chloro-N-(4-fluoro-2-hydroxyphenyl)acetamide

: 1610610-83-7
4-(5-(1-(7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)ethyl)pyrazolo[1,5-a]pyridin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 80 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / 20 °C

2.2: 20 °C / Reflux

3.1: potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris-(o-tolyl)phosphine / ethanol; water; toluene / 7 h / 90 °C

With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In tetrahydrofuran; ethanol; water; toluene; acetonitrile; 3.1: |Suzuki Coupling;

Reference yield:

: 1610611-93-2
3-bromo-5-ethylpyrazolo[1,5-a]pyridine

: 1610610-83-7
4-(5-(1-(7-fluoro-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)ethyl)pyrazolo[1,5-a]pyridin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 77 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / 20 °C

2.2: 20 °C / Reflux

3.1: potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris-(o-tolyl)phosphine / ethanol; water; toluene / 7 h / 90 °C

With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; potassium tert-butylate; tris-(o-tolyl)phosphine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; water; toluene; 3.1: |Suzuki Coupling;