4-(4-Bromo-phenyl)-5-cyano-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide

Base Information

• Chemical Name: 4-(4-Bromo-phenyl)-5-cyano-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide
• CAS No.: 201280-69-5
• Molecular Formula: C₂₀H₁₄BrN₃OS
• Molecular Weight: 424.321

Synonyms:4-(4-Bromo-phenyl)-5-cyano-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide

Chemical Property of 4-(4-Bromo-phenyl)-5-cyano-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide

Chemical Property:

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Technology Process of 4-(4-Bromo-phenyl)-5-cyano-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide

There total 1 articles about 4-(4-Bromo-phenyl)-5-cyano-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(E)-3-(4-bromophenyl)-2-cyanoprop-2-enethioamide (68029-54-9) + N-phenylacetoacetamide (102-01-2,98624-45-4) → 4-(4-Bromo-phenyl)-5-cyano-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide (201280-69-5)

Guidance literature:

With 4-methyl-morpholine; In ethanol; at 20 ℃; for 4h;

DOI:10.1007/BF02321397

Reference yield:

para-bromophenacyl bromide (99-73-0,132309-76-3) + 4-(4-Bromo-phenyl)-5-cyano-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide (201280-69-5) → 4-(4-Bromo-phenyl)-6-[2-(4-bromo-phenyl)-2-oxo-ethylsulfanyl]-5-cyano-2-methyl-N-phenyl-nicotinamide (201280-81-1)

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1) DMF, 1 min; 2) DMF, 2 h;

DOI:10.1007/BF02321397

Reference yield:

2-methylbenzyl bromide (89-92-9) + 4-(4-Bromo-phenyl)-5-cyano-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide (201280-69-5) → 4-(4-Bromo-phenyl)-5-cyano-2-methyl-6-(2-methyl-benzylsulfanyl)-N-phenyl-nicotinamide

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1) DMF, 1 min; 2) DMF, 2 h;

DOI:10.1007/BF02321397

upstream raw materials:

(E)-3-(4-bromophenyl)-2-cyanoprop-2-enethioamide

N-phenylacetoacetamide

Downstream raw materials:

4-(4-Bromo-phenyl)-6-[2-(4-bromo-phenyl)-2-oxo-ethylsulfanyl]-5-cyano-2-methyl-N-phenyl-nicotinamide

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